ArticleMolecular and cellular biology1997
Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.European journal of nutrition · 2017Pooled it
- LMX1B-associated gankyrin expression predicts poor prognosis in glioma patients.The Journal of international medical research · 2020Article
- Nail-patella syndrome.Pflugers Archiv : European journal of physiology · 2017Review
- Article
- A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].PLoS genetics · 2014Article
- The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.Molecular endocrinology (Baltimore, Md.) · 2013Article
- An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production.PLoS genetics · 2012Article
- Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.Diabetes · 2009Article
- LIM-homeodomain genes in mammalian development and human disease.Molecular biology reports · 2005Review
- NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression.The EMBO journal · 2004Article
- Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- A novel IL-10 signalling mechanism regulates TIMP-1 expression in human prostate tumour cells.British journal of cancer · 2003Article
- Mechanism of e47-Pip interaction on DNA resulting in transcriptional synergy and activation of immunoglobulin germ line sterile transcripts.Molecular and cellular biology · 2002Article
- Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Specific protein-protein interaction between basic helix-loop-helix transcription factors and homeoproteins of the Pitx family.Molecular and cellular biology · 2000Article
- The level of DLDB/CHIP controls the activity of the LIM homeodomain protein apterous: evidence for a functional tetramer complex in vivo.The EMBO journal · 2000Article
- The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.Molecular and cellular biology · 2000Article
- Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription.Molecular and cellular biology · 1999Article
- Mutation analysis of LMX1B gene in nail-patella syndrome patients.American journal of human genetics · 1998Article
- Transcription factor Pip can enhance DNA binding by E47, leading to transcriptional synergy involving multiple protein domains.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
LIM-homeodomain proteins direct cellular differentiation by activating transcription of cell-type-specific genes, but this activation requires cooperation with other nuclear factors. The LIM-homeodomain protein Lmx1 cooperates with the basic helix-loop-helix (bHLH) protein E47/Pan-1 to activate the insulin promoter in transfected fibroblasts. In this study, we show that two proteins originally called Lmx1 are the closely related products of two distinct vertebrate genes, Lmx1.1 and Lmx1.2. We have used yeast genetic systems to delineate the functional domains of the Lmx1 proteins and to characterize the physical interactions between Lmx1 proteins and E47/Pan-1 that produce synergistic transcriptional activation. The LIM domains of the Lmx1 proteins, and particularly the second LIM domain, mediate both specific physical interactions and transcriptional synergy with E47/Pan-1. The LIM domains of the LIM-homeodomain protein Isl-1, which cannot mediate transcriptional synergy with E47/Pan-1, do not interact with E47/Pan-1. In vitro studies demonstrate that the Lmx1.1 LIM2 domain interacts specifically with the bHLH domain of E47/Pan-1. These studies provide the basis for a model of the assembly of LIM-homeodomain-containing complexes on DNA elements that direct cell-type-restricted transcription in differentiated tissues.
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