ArticleJapanese journal of cancer research : Gann1997
Alternative splicing of the FHIT gene in colorectal cancers.
Article in Japanese journal of cancer research : Gann, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Significant Pattern of Promoter Hypermethylation of UNC5C Gene in Colorectal Cancer and Its Implication in Late Stage DiseaseAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer.World journal of surgery · 2009Article
- Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer.Frontiers of medicine in China · 2007Article
- Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition.World journal of gastroenterology · 2007Article
- Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer.British journal of cancer · 2005Article
- CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer.British journal of cancer · 2004Article
- Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma.British journal of cancer · 2002Article
- Colorectal cancers with both p16 and p14 methylation show invasive characteristics.Japanese journal of cancer research : Gann · 2002Article
- FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study.Clinical & experimental metastasis · 2002Article
- Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT.Journal of bacteriology · 1998Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we examined the status of the FHIT gene in 112 colorectal cancer and 137 colorectal adenoma specimens. In a total of 5 specimens (4 colorectal cancers and 1 colorectal adenoma), a common smaller product was detected in addition to the normal size product. This smaller product had lost exon 4, the 5' noncoding region of the FHIT gene, owing to alternative splicing. Moreover, all of the 5 tumors with alternative splicing were located lower on the rectum than the anterior peritoneal reflection.
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