ArticleIn vitro cellular & developmental biology. Animal1997
Microgravity tissue engineering.
Article in In vitro cellular & developmental biology. Animal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Hydrogel Formulation for Biomimetic Fibroblast Cell Culture: Exploring Effects of External Stresses and Cellular Responses.International journal of molecular sciences · 2024Article
- Structural and Molecular Changes of Human Chondrocytes Exposed to the Rotating Wall Vessel Bioreactor.Biomolecules · 2023Article
- A Workflow to Produce a Low-Cost In Vitro Platform for the Electric-Field Pacing of Cellularised 3D Porous Scaffolds.ACS biomaterials science & engineering · 2023Article
- Engineered Human Meniscus in Modeling Sex Differences of Knee OsteoarthritisFrontiers in bioengineering and biotechnology · 2022Article
- Engineered Microvessel for Cell Culture in Simulated Microgravity.International journal of molecular sciences · 2021Article
- Advances in space microbiology.iScience · 2021Review
- Microgravity × Radiation: A Space Mechanobiology Approach Toward Cardiovascular Function and Disease.Frontiers in cell and developmental biology · 2021Review
- Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors.Stem cell reports · 2018Article
- Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity.NPJ microgravity · 2017Article
- Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria.Pathogens and disease · 2016Review
- Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs.Journal of biomechanics · 2016Article
- Rotary bioreactor culture can discern specific behavior phenotypes in Trk-null and Trk-expressing neuroblastoma cell lines.In vitro cellular & developmental biology. Animal · 2014Article
- Flow characterization of a spinner flask for induced pluripotent stem cell culture application.PloS one · 2014Article
- Biomaterial strategies for alleviation of myocardial infarction.Journal of the Royal Society, Interface · 2012Review
- Mesenchymal stem cells from umbilical cord tissue as potential therapeutics for cardiomyodegenerative diseases - a review.International journal of molecular and cellular medicine · 2012Review
- An update to space biomedical research: tissue engineering in microgravity bioreactors.BioImpacts : BI · 2012Article
- A novel pulsatile bioreactor for mechanical stimulation of tissue engineered cardiac constructs.Journal of functional biomaterials · 2011Article
- Microgravity assay of neuroblastoma: in vitro aggregation kinetics and organoid morphology correlate with MYCN expression.In vitro cellular & developmental biology. Animal · 2011Article
- Proangiogenic scaffolds as functional templates for cardiac tissue engineering.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Generation of a tumor spheroid in a microgravity environment as a 3D model of melanoma.In vitro cellular & developmental biology. Animal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue engineering studies were done using isolated cells, three-dimensional polymer scaffolds, and rotating bioreactors operated under conditions of simulated microgravity. In particular, vessel rotation speed was adjusted such that 10 mm diameter x 2 mm thick cell-polymer constructs were cultivated in a state of continuous free-fall. Feasibility was demonstrated for two different cell types: cartilage and heart. Conditions of simulated microgravity promoted the formation of cartilaginous constructs consisting of round cells, collagen and glycosaminoglycan (GAG), and cardiac tissue constructs consisting of elongated cells that contracted spontaneously and synchronously. Potential advantages of using a simulated microgravity environment for tissue engineering were demonstrated by comparing the compositions of cartilaginous constructs grown under four different in vitro culture conditions: simulated microgravity in rotating bioreactors, solid body rotation in rotating bioreactors, turbulent mixing in spinner flasks, and orbital mixing in petri dishes. Constructs grown in simulated microgravity contained the highest fractions of total regenerated tissue (as a percent of construct dry weight) and of GAG, the component required for cartilage to withstand compressive force.
Indexed as
Identifiers
9196897What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.