ReviewOccupational and environmental medicine1997
Time to pregnancy: a measure of reproductive function in either sex. Asclepios Project.
Review in Occupational and environmental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review.Human reproduction update · 2019Pooled it
- Estimated costs for the delivery of safer conception strategies for HIV-discordant couples in Zimbabwe: a cost analysis.BMC health services research · 2020Trial
- Chlordecone exposure in women and time to pregnancy: the Timoun cohort study in Guadeloupe, French West Indies.Environmental health : a global access science source · 2025Article
- Fertility in a prospective Canadian cohort of women in the welding and electrical trades.Occupational and environmental medicine · 2025Article
- Assessment of Prior Infection With Hepatitis B Virus and Fecundability in Couples Planning Pregnancy.JAMA network open · 2023Article
- Article
- Persistent organic pollutants, pre-pregnancy use of combined oral contraceptives, age, and time-to-pregnancy in the SELMA cohort.Environmental health : a global access science source · 2020Article
- Association between peri-conceptional bisphenol A exposure in women and men and time to pregnancy-The HOPE study.Paediatric and perinatal epidemiology · 2019Article
- Mining leachate contamination and subfecundity among women living near the USA-Mexico border.Environmental geochemistry and health · 2019Article
- Pre-pregnancy maternal fasting plasma glucose levels in relation to time to pregnancy among the couples attempting first pregnancy.Human reproduction (Oxford, England) · 2019Article
- Low-level arsenic exposure via drinking water consumption and female fecundity - A preliminary investigation.Environmental research · 2017Article
- Increased time-to-pregnancy is associated with domestic work in South Africa.Reproductive health · 2016Article
- Lipid concentrations and couple fecundity: the LIFE study.The Journal of clinical endocrinology and metabolism · 2014Article
- Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study--the LIFE study.Human reproduction (Oxford, England) · 2014Article
- Misconceptions about falling sperm counts and fertility in Europe.Asian journal of andrology · 2013Review
- Reproductive and hormonal factors in association with ovarian cancer in the Netherlands cohort study.American journal of epidemiology · 2010Article
- Time-to-pregnancy and pregnancy outcomes in a South African population.BMC public health · 2010Article
- Time-to-pregnancy and risk of schizophrenia.Schizophrenia research · 2010Article
- Reproductive outcome in a cohort of male and female rubber workers: a registry study.International archives of occupational and environmental health · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGrowing evidence of reproductive effects associated with occupational and environmental agents has created the need for research with sensitive and well validated methods. There is a complex relation between manifest effects and underlying pathogenic processes. Conceptions will on average tend to be delayed in a population exposed to an agent that causes embryonic damage, an increase in germ cell mutations, or decreased fertility. STUDYING TIME TO PREGNANCY: Time to pregnancy can be used to measure the degree of delay in conceiving, across the whole continuum of biological fertility, in either men or women. The distribution of time to pregnancy largely reflects a sorting process, as the more fertile couples become progressively less well represented with the passage of time. The basic research strategy is comparison of the time to pregnancy within groups defined by their exposures, allowing for potential confounding factors relating not only to the study subject but also to his or her partner. MEASUREMENT AND VALIDITY: Prospective and retrospective methods are available, and each has strengths and weaknesses. Prospective studies have some theoretical advantages, but have unrepresentative populations and problems of feasibility and cost. Retrospective assessment of time to pregnancy is feasible with a short questionnaire, without intruding into sensitive areas of respondents' lives, with good validity at the group level, and without the necessity of large populations. Potential biases have been identified that can be minimised by careful design and analysis; the principal remaining problem is difficulty in obtaining exposure data retrospectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.