ArticleJournal of clinical microbiology1997
Study of internal transcribed spacer and mitochondrial large-subunit genes of Pneumocystis carinii hominis isolated by repeated bronchoalveolar lavage from human immunodeficiency virus-infected patients during one or several episodes of pneumonia.
Article in Journal of clinical microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Restriction fragment length polymorphism typing demonstrates substantial diversity among Pneumocystis jirovecii isolates.The Journal of infectious diseases · 2009Article
- Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure.Respiratory research · 2009Article
- Article
- Prevention of infection due to Pneumocystis spp. in human immunodeficiency virus-negative immunocompromised patients.Clinical microbiology reviews · 2004Review
- Genotyping and coalescent phylogenetic analysis of Pneumocystis jiroveci from South Africa.Journal of clinical microbiology · 2004Article
- Genotypes at the internal transcribed spacers of the nuclear rRNA operon of Pneumocystis jiroveci in nonimmunosuppressed infants without severe pneumonia.Journal of clinical microbiology · 2003Article
- Pneumocystis jiroveci internal transcribed spacer types in patients colonized by the fungus and in patients with pneumocystosis from the same French geographic region.Journal of clinical microbiology · 2003Article
- Pneumocystis carinii f. sp. hominis DNA in immunocompetent health care workers in contact with patients with P. carinii pneumonia.Journal of clinical microbiology · 2001Article
- Heterogeneity and compartmentalization of Pneumocystis carinii f. sp. hominis genotypes in autopsy lungs.Journal of clinical microbiology · 2001Article
- Genetic diversity of Pneumocystis carinii isolated from human immunodeficiency virus-positive patients in Turin, Italy.Journal of clinical microbiology · 2001Article
- Internal transcribed spacer regions of rRNA genes of Pneumocystis carinii from monkeys.Clinical and diagnostic laboratory immunology · 2001Article
- Determination of copy number of rRNA genes in Pneumocystis carinii f. sp. hominis.Journal of clinical microbiology · 1998Article
- Identification of Pneumocystis carinii f. sp. hominis gene sequences in filtered air in hospital environments.Journal of clinical microbiology · 1998Article
- Prevention of infection due to Pneumocystis carinii.Antimicrobial agents and chemotherapy · 1998Review
- Update on Pneumocystis carinii f. sp. hominis typing based on nucleotide sequence variations in internal transcribed spacer regions of rRNA genes.Journal of clinical microbiology · 1998Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to type, analyze, and compare Pneumocystis carinii hominis strains obtained from different samples during a given or recurrent episodes of P. carinii pneumonia (PCP) for epidemiologic purposes. We studied 36 bronchoalveolar lavage (BAL) or induced sputum (IS) samples from 16 human immunodeficiency virus-infected patients with one or several episodes of PCP. PCR amplification and direct sequencing were performed on the two internal transcribed spacers (ITS1 and ITS2) of P. carinii hominis rRNA genes by using DNA extracted from BAL or IS samples, and the sequences were compared to the mitochondrial large-subunit (mt LSU) gene sequence determined in a previous study in our laboratory. The studies of the mt LSU and ITS sequences showed that some patients (n = 10) were infected with the same strains of P. carinii hominis during a given episode of PCP. In one patient infected with strains with identical sequences in several episodes, the recurrence could have been due to reactivation of organisms not eliminated by treatment during the first episode or to de novo infection by an identical strain. In five patients infected with strains with different sequences in each episode, recurrence was due to de novo infection. Sequence analysis of these two P. carinii hominis gene regions showed that de novo infection can occur in AIDS patients with recurrent PCP.
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