ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Eyes absent: a gene family found in several metazoan phyla.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
- Identification of the CDH18 gene associated with age-related macular degeneration using weighted gene co-expression network analysis.Frontiers in genetics · 2024Article
- Eya2 expression during mouse embryonic development revealed by Eya2Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases.International journal of molecular sciences · 2021Review
- EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transcriptional regulation of cranial sensory placode development.Current topics in developmental biology · 2015Review
- Article
- The Eyes Absent proteins in development and disease.Cellular and molecular life sciences : CMLS · 2013Review
- EYA1 mutations associated with the branchio-oto-renal syndrome result in defective otic development in Xenopus laevis.Biology of the cell · 2010Article
- Distinct gene expression profile of human mesenchymal stem cells in comparison to skin fibroblasts employing cDNA microarray analysis of 9600 genes.Gene expression · 2005Article
- Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid.Development (Cambridge, England) · 2002Article
- Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain.Genetics · 2000Article
- Molecular genetic analysis of Drosophila eyes absent mutants reveals an eye enhancer element.Genetics · 2000Article
- Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.Molecular and cellular biology · 1999Article
- Expressed sequence tags from a root-hair-enriched medicago truncatula cDNA libraryPlant physiology · 1998Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes related to the Drosophila eyes absent gene were identified in vertebrates (mouse and human), mollusks (squid), and nematodes (C. elegans). Proteins encoded by these genes consist of conserved C-terminal and variable N-terminal domains. In the conserved 271-amino acid C-terminal region, Drosophila and vertebrate proteins are 65-67% identical. A vertebrate homolog of eyes absent, designated Eya2, was mapped to Chromosome (Chr) 2 in the mouse and to Chr 20q13.1 in human. Eya2 shows a dynamic pattern of expression during development. In the mouse, expression of Eya2 was first detected in 8.5-day embryos in the region of head ectoderm fated to become the forebrain. At later stages of development, Eya2 is expressed in the olfactory placode and in a variety of neural crest derivatives. In the eye, expression of Eya2 was first detected after formation of the lens vesicle. At day 17.5, the highest level of Eya2 mRNA was observed in primary lens fibers. Low levels of Eya2 expression was detected in retina, sclera, and cornea. By postnatal day 10, Eya2 was expressed in secondary lens fibers, cornea, and retina. Although Eya2 is expressed relatively late in eye development, it belongs to the growing list of factors that may be essential for eye development across metazoan phyla. Like members of the Pax-6 gene family, eyes absent gene family members were probably first involved in functions not related to vision, with recruitment for visual system formation and function occurring later.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.