ArticleProceedings of the National Academy of Sciences of the United States of America1997
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed.
- Phosphoregulation of RAD51AP1 function in homology-directed repair.bioRxiv : the preprint server for biology · 2025Article
- The Role of Rab GTPases in the development of genetic and malignant diseases.Molecular and cellular biochemistry · 2024Review
- Analysis of the indispensable RAD51 cofactor BRCA2 inLife science alliance · 2024Article
- Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.Nature communications · 2023Article
- [Research Advances of RAD51AP1 in Tumor Progression and Drug Resistance].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Review
- Article
- Article
- Validation of AmpliSeq NGS Panel forLife (Basel, Switzerland) · 2022Article
- Systematic pan-cancer analysis showed that RAD51AP1 was associated with immune microenvironment, tumor stemness, and prognosis.Frontiers in genetics · 2022Article
- Review
- BRD4 inhibition sensitizes cervical cancer to radiotherapy by attenuating DNA repair.Oncogene · 2021Article
- Endocytosis: a pivotal pathway for regulating metastasis.British journal of cancer · 2021Review
- Understanding Rad51 function is a prerequisite for progress in cancer research.QRB discovery · 2020Article
- How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?DNA repair · 2019Review
- Review
- Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair.Nucleic acids research · 2017Article
- A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.Genes & development · 2016Article
- Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity.Nucleic acids research · 2016Article
- Cyclin D1 promotes BRCA2-Rad51 interaction by restricting cyclin A/B-dependent BRCA2 phosphorylation.Oncogene · 2016Article
- BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.Journal of the National Cancer Institute · 2016Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
The human RAD51 protein is a homologue of the bacteria RecA and yeast RAD51 proteins that are involved in homologous recombination and DNA repair. RAD51 interacts with proteins involved in recombination and also with tumor suppressor proteins p53 and breast cancer susceptibility gene 1 (BRCA1). We have used the yeast two-hybrid system to clone murine cDNA sequences that encode two RAD51-associated molecules, RAB22 and RAB163. RAB163 encodes the C-terminal portion of mouse BRCA2, the homologue of the second breast cancer susceptibility gene protein in humans, demonstrating an in vitro association between RAD51 and BRCA2. RAB22 is a novel gene product that also interacts with RAD51 in vitro. To detect RAD51 interactions in vivo, we developed a transient nuclear focus assay that was used to demonstrate a complete colocalization of RAB22 with RAD51 in large nuclear foci.
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