ArticleProceedings of the National Academy of Sciences of the United States of America1997
The abalone egg vitelline envelope receptor for sperm lysin is a giant multivalent molecule.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 121 citations in OpenAlex.
- Integrating cryptic diversity into coral evolution, symbiosis and conservation.Nature ecology & evolution · 2024Review
- Divergent molecular signatures in fish Bouncer proteins define cross-fertilization boundaries.Nature communications · 2023Article
- Frequency-dependent viscosity of salmon ovarian fluid has biophysical implications for sperm-egg interactions.The Journal of experimental biology · 2023Article
- Rapid divergence of a gamete recognition gene promoted macroevolution of Eutheria.Genome biology · 2022Article
- Recurrent Duplication and Diversification of Acrosomal Fertilization Proteins in Abalone.Frontiers in cell and developmental biology · 2022Article
- Molecular mechanisms and evolution of fertilization proteins.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Review
- The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Proteomics support the threespine stickleback egg coat as a protective oocyte envelope.Molecular reproduction and development · 2021Article
- Article
- The Ly6/uPAR protein Bouncer is necessary and sufficient for species-specific fertilization.Science (New York, N.Y.) · 2018Article
- Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Egg Coat Proteins Across Metazoan Evolution.Current topics in developmental biology · 2018Review
- Genomic Signatures of Sexual Conflict.The Journal of heredity · 2017Article
- Parallel Evolution of Sperm Hyper-Activation Ca2+ Channels.Genome biology and evolution · 2017Article
- Article
- Easy mammalian expression and crystallography of maltose-binding protein-fused human proteins.Journal of structural biology · 2016Article
- From molecules to mating: Rapid evolution and biochemical studies of reproductive proteins.Journal of proteomics · 2016Review
- The challenges involved in elucidating the molecular basis of sperm-egg recognition in mammals and approaches to overcome them.Cell and tissue research · 2016Review
- Detecting coevolution in mammalian sperm-egg fusion proteins.Molecular reproduction and development · 2014Article
- Duplicate abalone egg coat proteins bind sperm lysin similarly, but evolve oppositely, consistent with molecular mimicry at fertilization.PLoS genetics · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Abalone sperm lysin is a 16-kDa acrosomal protein, which nonenzymatically and species selectively creates a hole in the egg vitelline envelope (VE) through which the sperm passes to reach the egg cell membrane. The crystal structures of both monomeric and dimeric lysins have been solved and the sequences of lysins from 20 abalone species have been determined. As a first step in understanding the molecular mechanism by which lysin creates a hole in the VE, its VE receptor was isolated. The VE receptor for lysin (VERL) is an unbranched, rod-like molecule with an approximate relative molecular mass of 2 million; half the mass being carbohydrate. Fluorescence polarization studies showed positive cooperativity in the binding of lysin to VERL (EC50 approximately 9 nM) and were consistent with the species selectivity of lysin in dissolving VEs. Each molecule of VERL bound between 126 and 142 molecules of monomeric lysin (two independent assays), showing that VERL possesses repetitive lysin-binding motifs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.