ArticleJournal of virology1997
Identification of an ATPase activity associated with a 71-kilodalton polypeptide encoded in gene 1 of the human coronavirus 229E.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites.The Journal of biological chemistry · 2026Article
- Genomic characterization of equine coronavirus.Virology · 2007Article
- Nidovirales: evolving the largest RNA virus genome.Virus research · 2006Review
- ADP-ribose-1"-monophosphatase: a conserved coronavirus enzyme that is dispensable for viral replication in tissue culture.Journal of virology · 2005Article
- A complex zinc finger controls the enzymatic activities of nidovirus helicases.Journal of virology · 2005Article
- The coronavirus replicase.Current topics in microbiology and immunology · 2005Review
- Human coronavirus 229E nonstructural protein 13: characterization of duplex-unwinding, nucleoside triphosphatase, and RNA 5'-triphosphatase activities.Journal of virology · 2004Article
- Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase.Journal of virology · 2004Article
- Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus.Virology · 2002Article
- Membrane association and dimerization of a cysteine-rich, 16-kilodalton polypeptide released from the C-terminal region of the coronavirus infectious bronchitis virus 1a polyprotein.Journal of virology · 2002Article
- Article
- Viral replicase gene products suffice for coronavirus discontinuous transcription.Journal of virology · 2001Article
- Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases.Journal of virology · 2000Article
- The human coronavirus 229E superfamily 1 helicase has RNA and DNA duplex-unwinding activities with 5'-to-3' polarity.RNA (New York, N.Y.) · 2000Article
- Further characterization of the coronavirus infectious bronchitis virus 3C-like proteinase and determination of a new cleavage site.Virology · 2000Article
- The predicted metal-binding region of the arterivirus helicase protein is involved in subgenomic mRNA synthesis, genome replication, and virion biogenesis.Journal of virology · 2000Article
- Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly.Journal of virology · 2000Article
- Further requirements for cleavage by the murine coronavirus 3C-like proteinase: identification of a cleavage site within ORF1b.Virology · 1999Article
- The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis.Journal of virology · 1999Article
- Activity of a purified His-tagged 3C-like proteinase from the coronavirus infectious bronchitis virus.Virus research · 1999Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human coronavirus 229E gene expression involves proteolytic processing of the gene 1-encoded polyproteins pp1a and pp1ab. In this study, we have detected a 71-kDa polypeptide in virus-infected cells that is released from pp1ab by the virus-encoded 3C-like proteinase and that has been predicted to contain both metal-binding and helicase domains. The polypeptide encompasses amino acids Ala-4996 to Gln-5592 of pp1ab and exhibits nucleic acid-stimulated ATPase activity when expressed as a fusion protein with the Escherichia coli maltose-binding protein. These data provide the first identification of a coronavirus open reading frame 1b-encoded enzymatic activity.
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