ArticleJournal of virology1997
cis-Acting sequences in addition to donor and acceptor sites are required for template switching during synthesis of plus-strand DNA for duck hepatitis B virus.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis.Journal of virology · 2022Article
- Molecular biology of the hepatitis B virus for clinicians.Journal of clinical and experimental hepatology · 2012Review
- cis-Acting sequences that contribute to synthesis of minus-strand DNA are not conserved between hepadnaviruses.Journal of virology · 2010Article
- Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation.Journal of virology · 2007Article
- Base pairing between cis-acting sequences contributes to template switching during plus-strand DNA synthesis in human hepatitis B virus.Journal of virology · 2007Article
- 5'-proximal hot spot for an inducible positive-to-negative-strand template switch by coronavirus RNA-dependent RNA polymerase.Journal of virology · 2007Article
- Complementarity between epsilon and phi sequences in pregenomic RNA influences hepatitis B virus replication efficiency.Virology · 2007Article
- Regulation of hepadnavirus reverse transcription by dynamic nucleocapsid phosphorylation.Journal of virology · 2007Article
- Hepatitis B virus replication.World journal of gastroenterology · 2007Review
- Sequence identity of the direct repeats, DR1 and DR2, contributes to the discrimination between primer translocation and in situ priming during replication of the duck hepatitis B virus.Journal of molecular biology · 2006Article
- Three novel cis-acting elements required for efficient plus-strand DNA synthesis of the hepatitis B virus genome.Journal of virology · 2004Article
- cis-Acting sequences that contribute to the synthesis of relaxed-circular DNA of human hepatitis B virus.Journal of virology · 2004Article
- Template switches during plus-strand DNA synthesis of duck hepatitis B virus are influenced by the base composition of the minus-strand terminal redundancy.Journal of virology · 2003Article
- The conformation of the 3' end of the minus-strand DNA makes multiple contributions to template switches during plus-strand DNA synthesis of duck hepatitis B virus.Journal of virology · 2003Article
- Mismatch extension during strong stop strand transfer and minimal homology requirements for replicative template switching during Moloney murine leukemia virus replication.Journal of molecular biology · 2003Article
- Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Characterization of the cis-acting contributions to avian hepadnavirus RNA encapsidation.Journal of virology · 2002Article
- cis-Acting sequences 5E, M, and 3E interact to contribute to primer translocation and circularization during reverse transcription of avian hepadnavirus DNA.Journal of virology · 2002Article
- Analysis of duck hepatitis B virus reverse transcription indicates a common mechanism for the two template switches during plus-strand DNA synthesis.Journal of virology · 2002Article
- Small DNA hairpin negatively regulates in situ priming during duck hepatitis B virus reverse transcription.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A characteristic of all hepadnaviruses is the relaxed-circular conformation of the DNA genome within an infectious virion. Synthesis of the relaxed-circular genome by reverse transcription requires three template switches. These template switches, as for the template switches or strand transfers of other reverse-transcribing genetic elements, require repeated sequences (the donor and acceptor sites) between which a complementary strand of nucleic acid is transferred. The mechanism for each of the template switches in hepadnaviruses is poorly understood. To determine whether sequences other than the donor and acceptor sites are involved in the template switches of duck hepatitis B virus (DHBV), a series of molecular clones which express viral genomes bearing deletion mutations were analyzed. We found that three regions of the DHBV genome, which are distinct from the donor and acceptor sites, are required for the synthesis of relaxed-circular DNA. One region, located near the 3' end of the minus-strand template, is required for the template switch that circularizes the genome. The other two regions, located in the middle of the genome and near DR2, appear to be required for plus-strand primer translocation. We speculate that these cis-acting sequences may play a role in the organization of the minus-strand DNA template within the capsid particle so that it supports efficient template switching during plus-strand DNA synthesis.
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