ArticleJournal of virology1997
The product of the adenovirus intermediate gene IX is a transcriptional activator.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- Review
- Article
- E1B-55K Is a Phosphorylation-Dependent Transcriptional and Posttranscriptional Regulator of Viral Gene Expression in Human Adenovirus C5 Infection.Journal of virology · 2022Article
- Distinct codon usage bias evolutionary patterns between weakly and strongly virulent respiratory viruses.iScience · 2022Article
- Adipocyte commitment of 3T3-L1 cells is required to support human adenovirus 36 productive replication concurrent with altered lipid and glucose metabolism.Frontiers in cellular and infection microbiology · 2022Article
- Fusion of Large Polypeptides to Human Adenovirus Type 5 Capsid Protein IX Can Compromise Virion Stability and DNA Packaging Capacity.Journal of virology · 2020Article
- Viral and cellular interactions during adenovirus DNA replication.FEBS letters · 2019Review
- Progress in Adenoviral Capsid-Display Vaccines.Biomedicines · 2018Review
- Bovine adenovirus type 3 virions cannot be rescuedJournal of veterinary science · 2017Article
- Virion factors that target Daxx to overcome intrinsic immunity.Journal of virology · 2013Review
- A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.PloS one · 2011Article
- Identification of a previously unrecognized promoter that drives expression of the UXP transcription unit in the human adenovirus type 5 genome.Journal of virology · 2010Article
- Adenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression.Journal of virology · 2009Article
- Genomic and bioinformatics analysis of human adenovirus type 37: new insights into corneal tropism.BMC genomics · 2008Article
- Targeting of adenovirus vectors carrying a tumor cell-specific peptide: in vitro and in vivo studies.Cancer gene therapy · 2007Article
- Thermostability/infectivity defect caused by deletion of the core protein V gene in human adenovirus type 5 is rescued by thermo-selectable mutations in the core protein X precursor.Journal of molecular biology · 2007Article
- Review
- The coiled-coil domain of the adenovirus type 5 protein IX is dispensable for capsid incorporation and thermostability.Journal of virology · 2005Article
- Activation of adenoviral gene expression by protein IX is not required for efficient virus replication.Journal of virology · 2004Article
- Adenovirus protein IX sequesters host-cell promyelocytic leukaemia protein and contributes to efficient viral proliferation.EMBO reports · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the functional properties of the product of the adenovirus type 5 gene IX. This gene, which is expressed at intermediate times postinfection, encodes a small polypeptide (pIX) of 140 residues that has previously been shown to be incorporated into the viral capsid. Here, we show that pIX, in addition to its structural contribution, exhibits transcriptional properties. In transient transfection experiments, expression of pIX stimulated adenovirus major late promoter activity. The effect was independent of other viral proteins, but the level of promoter activation appeared strongly pIX dose dependent; similar levels of induction were observed with other cellular or viral TATA-containing (but not with TATA-less) promoters. This promoter specificity could be reproduced in a cell-free transcription system by the addition of purified recombinant pIX, further stressing the transcriptional nature of the phenomenon. A preliminary structural analysis of pIX indicated that the integrity of a putative leucine zipper at the carboxy-terminal end of the molecule, as well as elements within the amino-terminal half, was critical for pIX transcriptional activity. The relevance of these findings in adenovirus infection is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.