ArticleJournal of virology1997
In vivo dynamics of equine infectious anemia viruses emerging during febrile episodes: insertions/duplications at the principal neutralizing domain.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 citations in OpenAlex.
- Article
- The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5.The Journal of biological chemistry · 2019Article
- Antibody escape kinetics of equine infectious anemia virus infection of horses.Journal of virology · 2015Article
- Lessons in AIDS vaccine development learned from studies of equine infectious, anemia virus infection and immunity.Viruses · 2013Review
- Article
- Development of a high throughput, semi-automated, infectious center cell-based ELISA for equine infectious anemia virus.Journal of virological methods · 2012Article
- Unique evolution characteristics of the envelope protein of EIAV(LN₄₀), a virulent strain of equine infectious anemia virus.Virus genes · 2011Article
- Molecular detection, epidemiology, and genetic characterization of novel European field isolates of equine infectious anemia virus.Journal of clinical microbiology · 2011Article
- Divergence, not diversity of an attenuated equine lentivirus vaccine strain correlates with protection from disease.Vaccine · 2010Article
- An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family.Retrovirology · 2009Article
- The remarkable frequency of human immunodeficiency virus type 1 genetic recombination.Microbiology and molecular biology reviews : MMBR · 2009Review
- In silico segmentations of lentivirus envelope sequences.BMC bioinformatics · 2007Article
- Incorporating indel information into phylogeny estimation for rapidly emerging pathogens.BMC evolutionary biology · 2007Article
- Discerning an effective balance between equine infectious anemia virus attenuation and vaccine efficacy.Journal of virology · 2005Article
- Influence of long terminal repeat and env on the virulence phenotype of equine infectious anemia virus.Journal of virology · 2004Article
- Equine infectious anemia virus envelope evolution in vivo during persistent infection progressively increases resistance to in vitro serum antibody neutralization as a dominant phenotype.Journal of virology · 2002Article
- Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies.Journal of virology · 2001Article
- Conservation of human immunodeficiency virus type 1 gp120 inner-domain sequences in lentivirus and type A and B retrovirus envelope surface glycoproteins.Journal of virology · 2001Article
- Detection and induction of equine infectious anemia virus-specific cytotoxic T-lymphocyte responses by use of recombinant retroviral vectors.Journal of virology · 1999Article
- Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony.Journal of virology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Equine infectious anemia virus (EIAV) is a good model for studying mechanisms generating escaped retrovirus variants. We previously sequenced the entire gp90-encoding region of 22 cDNA clones obtained from five antigenically distinct isolates (F1V to F5V) recovered during febrile episodes in horse 493 experimentally infected with the Japanese virulent EIAV strain V70. The results showed that the mutations occurred in the principal neutralizing domain (PND) by insertions/duplications. In this study, we further characterized the PND of virus isolates sequentially recovered during 22 febrile episodes in seven horses newly infected with V70 or one of the V70-derived variants. Sequencing of 70 cDNA clones derived from the 22 episodes confirmed the generation of various new viral quasispecies with insertions/duplications in the PND. Although the insertion/duplication sequences in a total of 92 cDNA clones were extensively heterogeneous, we hypothesized that all the insertions/duplications occurred during reverse transcription from viral genomic RNA to minus strand DNA. The insertion/duplication regions were derived from a part of the PND sequence, which consisted of five small units. These small units, some with various substitutions and/or deletions, were also generated, especially in regions with insertions/duplications. Of particular note was that all these virus variants, except for two cDNA variants, were generated by essentially four different duplication pathways. Thus, these results extend the significance of insertions/duplications in the PND to the novel generation of EIAV in vivo during febrile episodes.
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