ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Recovery of neurofilament expression selectively in regenerating reticulospinal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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Who cites it
50 citing papers in PubMed, 117 citations in OpenAlex.
- Spontaneous regeneration of cholecystokinergic reticulospinal axons after a complete spinal cord injury in sea lampreys.Computational and structural biotechnology journal · 2024Article
- Spinal cord injury significantly alters the properties of reticulospinal neurons: delayed repolarization mediated by potassium channels.Journal of neurophysiology · 2023Article
- Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury.Frontiers in cellular neuroscience · 2023Article
- Lampreys and spinal cord regeneration: "a very special claim on the interest of zoologists," 1830s-present.Frontiers in cell and developmental biology · 2023Article
- Article
- Morpholino studies shed light on the signaling pathways regulating axon regeneration in lampreys.Neural regeneration research · 2022Article
- Full regeneration of descending corticotropin-releasing hormone axons after a complete spinal cord injury in lampreys.Computational and structural biotechnology journal · 2022Article
- The Composition and Cellular Sources of CSPGs in the Glial Scar After Spinal Cord Injury in the Lamprey.Frontiers in molecular neuroscience · 2022Article
- Survival and Axonal Outgrowth of the Mauthner Cell Following Spinal Cord Crush Does Not Drive Post-injury Startle Responses.Frontiers in cell and developmental biology · 2021Article
- Chondroitinase ABC Promotes Axon Regeneration and Reduces Retrograde Apoptosis Signaling in Lamprey.Frontiers in cell and developmental biology · 2021Article
- Source of Early Regenerating Axons in Lamprey Spinal Cord Revealed by Wholemount Optical Clearing with BABB.Cells · 2020Article
- Heterogeneity in the regenerative abilities of central nervous system axons within species: why do some neurons regenerate better than others?Neural regeneration research · 2020Review
- Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?Frontiers in cellular neuroscience · 2020Article
- Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury.Frontiers in cell and developmental biology · 2020Article
- Activated Erk Is an Early Retrograde Signal After Spinal Cord Injury in the Lamprey.Frontiers in neuroscience · 2020Article
- Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys.Disease models & mechanisms · 2019Article
- Regenerative capacity in the lamprey spinal cord is not altered after a repeated transection.PloS one · 2019Article
- RhoA activation in axotomy-induced neuronal death.Experimental neurology · 2018Article
- GABA promotes survival and axonal regeneration in identifiable descending neurons after spinal cord injury in larval lampreys.Cell death & disease · 2018Article
- The Effect of Axon Resealing on Retrograde Neuronal Death after Spinal Cord Injury in Lamprey.Brain sciences · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
During regeneration of lamprey spinal axons, growth cones lack filopodia and lamellipodia, contain little actin, and elongate much more slowly than do typical growth cones of embryonic neurons. Moreover, these regenerating growth cones are densely packed with neurofilaments (NFs). Therefore, after spinal hemisection the time course of changes in NF mRNA expression was correlated with the probability of regeneration for each of 18 identified pairs of reticulospinal neurons and 12 cytoarchitectonic groups of spinal projecting neurons. During the first 4 weeks after operation, NF message levels were reduced dramatically in all axotomized reticulospinal neurons, on the basis of semiquantitative in situ hybridization for the single lamprey NF subunit (NF-180). Thereafter, NF expression returned toward normal in neurons whose axons normally regenerate beyond the transection but remained depressed in poorly regenerating neurons. The recovery of NF expression in good regenerators was independent of axon growth across the lesion, because excision of a segment of spinal cord caudal to the transection site blocked regeneration but did not prevent the return of NF-180 mRNA. The early decrease in NF mRNA expression was not accompanied by a reduction in NF protein content. Thus the axotomy-induced loss of most of the axonal volume resulted in a reduced demand for NF rather than a reduction in volume-specific NF synthesis. We conclude that the secondary upregulation of NF message during axonal regeneration in the lamprey CNS may be part of an intrinsic growth program executed only in neurons with a strong propensity for regeneration.
Indexed as
Identifiers
9185558PMC6573315W2100045176What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.