ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
NMDA receptor and the tyrosine phosphorylation of its 2B subunit in taste learning in the rat insular cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 233 citations in OpenAlex.
- Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Article
- Chemospecific deficits in taste sensitivity following bilateral or right hemispheric gustatory cortex lesions in rats.The Journal of comparative neurology · 2020Article
- Taste Processing: Insights from Animal Models.Molecules (Basel, Switzerland) · 2020Review
- Sex Differences in Cue Competition Effects With a Conditioned Taste Aversion Preparation.Frontiers in behavioral neuroscience · 2020Article
- Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice.Heliyon · 2017Article
- Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice.Journal of psychiatry & neuroscience : JPN · 2017Article
- ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion.Nature communications · 2016Article
- The Role of Ephs and Ephrins in Memory Formation.The international journal of neuropsychopharmacology · 2016Review
- Opposing Roles of Cholinergic and GABAergic Activity in the Insular Cortex and Nucleus Basalis Magnocellularis during Novel Recognition and Familiar Taste Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Bilateral lesions in a specific subregion of posterior insular cortex impair conditioned taste aversion expression in rats.The Journal of comparative neurology · 2016Article
- A molecular mechanism underlying gustatory memory trace for an association in the insular cortex.eLife · 2015Article
- Effect of preexposure on methylphenidate-induced taste avoidance and related BDNF/TrkB activity in the insular cortex of the rat.Psychopharmacology · 2015Article
- Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines.Neuropharmacology · 2015Article
- Glycine receptors containing α2 or α3 subunits regulate specific ethanol-mediated behaviors.The Journal of pharmacology and experimental therapeutics · 2015Article
- Extensive Gustatory Cortex Lesions Significantly Impair Taste Sensitivity to KCl and Quinine but Not to Sucrose in Rats.PloS one · 2015Article
- Extensive lesions in rat insular cortex significantly disrupt taste sensitivity to NaCl and KCl and slow salt discrimination learning.PloS one · 2015Article
- High-resolution lesion-mapping strategy links a hot spot in rat insular cortex with impaired expression of taste aversion learning.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Dopamine-induced tyrosine phosphorylation of NR2B (Tyr1472) is essential for ERK1/2 activation and processing of novel taste information.Frontiers in molecular neuroscience · 2014Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate that the NMDA receptor is involved in taste learning in the insular cortex of the behaving rat and describe two facets of this involvement. Blockage of the NMDA receptor in the insular cortex by the reversible antagonist APV during training in a conditioned taste aversion (CTA) paradigm impaired CTA memory, whereas blockage of the NMDA receptor in an adjacent cortex or before a retrieval test had no effect. When rats sampled an unfamiliar taste and hence learned about it, either incidentally or in the context of CTA training, the tyrosine phosphorylation of the NMDA receptor subunit 2B (NR2B) in the insular cortex was specifically increased. The level of tyrosine phosphorylation on NR2B was a function of the novelty of the taste stimulus and the quantity of the taste substance consumed, properties that also determined the efficacy of the taste stimulus as a conditioned stimulus in CTA; however, blockage of the NMDA receptor by APV during training did not prevent tyrosine phosphorylation of NR2B. We suggest that tyrosine phosphorylation of NR2B subserves encoding of saliency in the insular cortex during the first hours after an unfamiliar taste is sampled and that this encoding is independent of another, necessary role of NMDA receptors in triggering experience-dependent modifications in the insular cortex during taste learning. Because a substantial fraction of the NR2B protein in the insular cortex seems to be expressed in interneurons, saliency and the tyrosine phosphorylation of NR2B correlated with it may modulate inhibition in cortex.
Indexed as
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9185550PMC6573317W2158929612What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.