ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 89 citations in OpenAlex.
- Increased expression of the proapoptotic presenilin associated protein is involved in neuronal tangle formation in human brain.Scientific reports · 2024Article
- Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons.Autonomic neuroscience : basic & clinical · 2023Article
- Alzheimer's disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.The EMBO journal · 2015Article
- Differential release of β-amyloid from dendrite- versus axon-targeted APP.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Early onset Alzheimer's disease and oxidative stress.Oxidative medicine and cellular longevity · 2014Review
- CSF Presenilin-1 complexes are increased in Alzheimer's disease.Acta neuropathologica communications · 2013Article
- γ-secretase binding sites in aged and Alzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF Aβ.The European journal of neuroscience · 2013Article
- DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP).The Journal of biological chemistry · 2011Article
- Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.Biochimica et biophysica acta · 2011Review
- Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations.The American journal of pathology · 2010Article
- Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover.Biochemical and biophysical research communications · 2006Article
- Cholesterol inhibits the insertion of the Alzheimer's peptide Abeta(25-35) in lipid bilayers.European biophysics journal : EBJ · 2006Article
- Presenilin 1 forms aggresomal deposits in response to heat shock.Journal of molecular neuroscience : MN · 2006Article
- Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation.The American journal of pathology · 2005Article
- Presenilin-2 in the cynomolgus monkey brain: investigation of age-related changes.Primates; journal of primatology · 2004Article
- Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease.Neurochemical research · 2002Article
- Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease.The American journal of pathology · 2001Article
- Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Mutations in the presenilin-1 (PS1) gene is a cause of early- onset familial Alzheimer's disease (AD). Endogenous PS1 is associated with the endoplasmic reticulum in the cell body of undifferentiated SH-SY5Y neuroblastoma cells. At early stages of neuronal differentiation in rat hippocampal culture, PS1 appears in all neuritic processes and in growth cones. In mature differentiated neurons, PS1 is concentrated in the somatodendritic compartment but is also present at lower levels in axons. A similar localization of PS1 is observed in vivo in neurons of the adult human cerebral cortex. In sporadic AD, PS1 appears in the dystrophic neurites of mature amyloid plaques and co-localizes with a subset of intraneuronal neurofibrillary tangles (NFTs). About 30% of hippocampal NFTs are labeled with a highly specific antibody to the PS1 C-terminal loop domain but not with an antibody to the PS1 N terminus. This observation is consistent with a potential association of the PS1 C-terminal fragment with NFTs, because PS1 is constitutively cleaved to N- and C-terminal fragments in neurons. These results suggest that PS1 is highly expressed and broadly distributed during early stages of neuronal differentiation, consistent with a role for PS1 in neuronal differentiation. Furthermore, the co-localization of PS1 with NFTs and plaque dystrophic neurites implicates a role for PS1 in the diverse pathological manifestations of AD.
Indexed as
Identifiers
9185547PMC6573321W1952363942What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.