ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Four Seasons for Schwann Cell Biology, Revisiting Key Periods: Development, Homeostasis, Repair, and Aging.Biomolecules · 2021Review
- Mechanisms of sodium channel clustering and its influence on axonal impulse conduction.Cellular and molecular life sciences : CMLS · 2016Review
- The Polarity Protein Pals1 Regulates Radial Sorting of Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The role of sodium channels in chronic pain.Muscle & nerve · 2012Review
- Unmyelinated nerve fibers in the human dental pulp express markers for myelinated fibers and show sodium channel accumulations.BMC neuroscience · 2012Article
- Schwann cells inhibit ectopic clustering of axonal sodium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury.BMC neuroscience · 2007Article
- Sodium channels and multiple sclerosis: roles in symptom production, damage and therapy.Brain pathology (Zurich, Switzerland) · 2007Review
- Both laminin and Schwann cell dystroglycan are necessary for proper clustering of sodium channels at nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath.Neuron glia biology · 2004Article
- Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier.The Journal of cell biology · 2003Article
- Initiation of sodium channel clustering at the node of Ranvier in the mouse optic nerve.Neurochemical research · 2003Article
- New insights into neuron-glia communication.Science (New York, N.Y.) · 2002Review
- Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr.The Journal of cell biology · 2002Article
- Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing.The Journal of cell biology · 1998Article
- Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains.The Journal of cell biology · 1998Article
- The effect of the mouse mutation claw paw on myelination and nodal frequency in sciatic nerves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- A novel crystallization method for visualizing the membrane localization of potassium channels.Biophysical journal · 1998Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The distribution of voltage-sensitive sodium channels on axons in the dorsal and ventral spinal roots of the dystrophic mouse 129/ReJ-Lama2dy was determined via immunocytochemistry. In these nerves there are regions in which Schwann cells fail to proliferate and myelinate axons in a normal manner, leaving bundles of closely packed large-diameter amyelinated axons. We have identified discrete and focal concentrations of sodium channel immunoreactivity on these axons by both confocal immunofluorescence and immunoelectron microscopy, using a peptide-derived polyclonal antibody. In addition, simultaneous labeling with an antibody recognizing neuronal-specific ankyrinG revealed a distinct colocalization with the sodium channels on both normal and amyelinated axons. The presence of patches of sodium channels along with their anchoring protein on amyelinated axons in the absence of intervening Schwann cells demonstrates that axons can form and maintain independently these initial aggregations. This confirms that direct contact between Schwann cell and axon is not required for the formation of sodium channel patches of nodal dimensions and density. Furthermore, this strongly suggests that local transfer of sodium channels from Schwann cells to axons is not required for this process.
Indexed as
Identifiers
9185545PMC6573302W1612840685What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.