ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Site-specific and sensory neuron-dependent increases in postsynaptic glutamate sensitivity accompany serotonin-induced long-term facilitation at Aplysia sensorimotor synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Generation of active expiration by serotoninergic mechanisms of the ventral medulla of rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Nonassociative learning in invertebrates.Cold Spring Harbor perspectives in biology · 2015Review
- cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The less things change, the more they are different: contributions of long-term synaptic plasticity and homeostasis to memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: implications for pain and memory.Neurobiology of learning and memory · 2013Review
- Reconsolidation of long-term memory in Aplysia.Current biology : CB · 2012Article
- Mapping molecular memory: navigating the cellular pathways of learning.Cellular and molecular neurobiology · 2012Review
- Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dscam mediates remodeling of glutamate receptors in Aplysia during de novo and learning-related synapse formation.Neuron · 2009Article
- Postsynaptic regulation of long-term facilitation in Aplysia.Current biology : CB · 2008Article
- New tricks for an old slug: the critical role of postsynaptic mechanisms in learning and memory in Aplysia.Progress in brain research · 2008Review
- Protein kinase C regulates local synthesis and secretion of a neuropeptide required for activity-dependent long-term synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Synaptogenesis regulates axotomy-induced activation of c-Jun-activator protein-1 transcription.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Synaptic facilitation and behavioral dishabituation in Aplysia: dependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Memory-like alterations in Aplysia axons after nerve injury or localized depolarization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Target-dependent release of a presynaptic neuropeptide regulates the formation and maturation of specific synapses in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Coregulation of glutamate uptake and long-term sensitization in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Long-term changes in the efficacy of Aplysia sensory neuron (SN) connections accompany behavioral training or applications with 5-HT. The changes evoked by training or 5-HT include formation of new SN varicosities and transmitter release sites. Because new synapse formation requires proper alignment of presynaptic structures with postsynaptic zones containing a high density of transmitter receptors, we examined whether changes in postsynaptic sensitivity to the presumed SN transmitter (glutamate) were correlated with formation and distribution of new SN varicosities in contact with motor cell L7 in cell culture. The formation of stable SN connections after 4 d in culture did not significantly change overall responses to focal applications of glutamate. However, specific sites along L7's axon apposed to SN varicosities expressed larger responses to glutamate compared with adjacent sites with few SN varicosities. After treatments with 5-HT that evoked long-term changes in both the structure and the function of SN-L7 synaptic interaction, glutamate responses increased selectively at sites along the surface of L7's axon with preexisting or new SN varicosities. Increases in postsynaptic response to glutamate 24 hr after 5-HT treatment required interaction with an SN. These results suggest that new synapse formation between neurons, either with regeneration or after external stimuli that evoke increases in synaptic efficacy, involves site-specific changes in expression of functional neurotransmitter receptors on the postsynaptic cell that is regulated by interaction with the presynaptic neuron.
Indexed as
Identifiers
9185535PMC6573320W1815483998What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.