ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Microtubule organization and stability in the oligodendrocyte.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 98 citations in OpenAlex.
- Spatially patterned cytoskeletal organization shapes astrocyte branch complexity.bioRxiv : the preprint server for biology · 2025Article
- Can repetitive mechanical motion cause structural damage to axons?Frontiers in molecular neuroscience · 2024Review
- The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis.European journal of cell biology · 2023Article
- Axonal architecture of the mouse inner retina revealed by second harmonic generation.PNAS nexus · 2022Article
- The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo.PLoS biology · 2021Article
- Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases.Frontiers in neuroscience · 2021Review
- N-Wasp Regulates Oligodendrocyte Myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- NDE1 positively regulates oligodendrocyte morphological differentiation.Scientific reports · 2018Article
- Dynein/dynactin is necessary for anterograde transport ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination.Annals of neurology · 2017Article
- Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia.Scientific reports · 2017Article
- Partial Immunoblotting of 2D-Gels: A Novel Method to Identify Post-Translationally Modified Proteins Exemplified for the Myelin Acetylome.Proteomes · 2017Article
- Paclitaxel improves outcome from traumatic brain injury.Brain research · 2015Article
- CNS myelination requires cytoplasmic dynein function.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Analysis of chemokines and receptors expression profile in the myelin mutant taiep rat.Oxidative medicine and cellular longevity · 2015Article
- Oligodendrocytes in a Nutshell.Frontiers in cellular neuroscience · 2015Review
- Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation.PloS one · 2015Article
- Adenomatous polyposis coli regulates oligodendroglial development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The oligodendrocyte is the glial cell responsible for the formation and maintenance of CNS myelin. Because the development of neuronal morphology is known to depend on the presence of highly organized microtubule arrays, it may be hypothesized that the properties of microtubules influence the form and function of oligodendrocytes. The goals of the present study were to define the physical attributes of microtubules in oligodendrocytes maintained in vitro. The results of electron and confocal microscopy indicate that microtubules are present throughout the cell bodies and large and small processes of oligodendrocytes and are rarely associated with discrete microtubule-organizing centers. A modified "hooking" protocol demonstrated that the polarity orientation of microtubules is uniformly plus-end distal in small oligodendrocyte processes, compared with a nonuniform, predominantly plus-end distal orientation in large processes. Oligodendrocytes were exposed to the microtubule-depolymerizing drug nocodazole to examine microtubule stability in these cells. The results suggest that oligodendrocyte microtubules can be resolved into at least three distinct microtubule populations that differ in their kinetics of depolymerization in the presence of nocodazole. These findings suggest that the properties of the oligodendrocyte microtubule array reflect the functions of the different regions of this highly specialized cell.
Indexed as
Identifiers
9185530PMC6573322W1519983393What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.