ArticleThe Journal of cell biology1997
Fission yeast dim1(+) encodes a functionally conserved polypeptide essential for mitosis.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
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- Tri-snRNP activity modulates tauopathy phenotypes.NAR molecular medicine · 2025Article
- Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins.The EMBO journal · 2024Article
- Isolation of mutant alleles of the U6 snRNA mmicroPublication biology · 2023Article
- The expression pattern of OsDim1 in rice and its proposed function.Scientific reports · 2019Article
- Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis.Disease models & mechanisms · 2018Article
- In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.Molecular psychiatry · 2015Article
- Splicing factor Spf30 assists exosome-mediated gene silencing in fission yeast.Molecular and cellular biology · 2010Article
- TvDim1 of Trichoderma virens is involved in redox-processes and confers resistance to oxidative stresses.Current genetics · 2010Article
- Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference.PLoS genetics · 2008Article
- Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.Eukaryotic cell · 2005Article
- Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression).Oncogene · 2002Article
- Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae.RNA (New York, N.Y.) · 2001Article
- The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase.Plant physiology · 2000Article
- Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The schizosaccharomyces pombe dim1(+) gene interacts with the anaphase-promoting complex or cyclosome (APC/C) component lid1(+) and is required for APC/C function.Molecular and cellular biology · 1999Article
- Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In a screen for second site mutations capable of reducing the restrictive temperature of the fission yeast mutant cdc2-D217N, we have isolated a novel temperature-sensitive mutant, dim1-35. When shifted to restrictive temperature, dim1-35 mutant cells arrest before entry into mitosis or proceed through mitosis in the absence of nuclear division, demonstrating an uncoupling of proper DNA segregation from other cell cycle events. Deletion of dim1 from the Schizosaccharomyces pombe genome produces a lethal G2 arrest phenotype. Lethality is rescued by overexpression of the mouse dim1 homolog, mdim1. Likewise, deletion of the Saccharomyces cerevisiae dim1 homolog, CDH1, is lethal. Both mdim1 and dim1(+) are capable of rescuing lethality in the cdh1::HIS3 mutant. Although dim1-35 displays no striking genetic interactions with various other G2/M or mitotic mutants, dim1-35 cells incubated at restrictive temperature arrest with low histone H1 kinase activity. Morevoer, dim1-35 displays sensitivity to the microtubule destabilizing drug, thiabendazole (TBZ). We conclude that Dim1p plays a fundamental, evolutionarily conserved role as a protein essential for entry into mitosis as well as for chromosome segregation during mitosis. Based on TBZ sensitivity and failed chromosome segregation in dim1-35, we further speculate that Dim1p may play a role in mitotic spindle formation and/or function.
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Registered trials
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