ArticleGenetics1997
Ancestral polymorphism of Mhc class II genes in mice: implications for balancing selection and the mammalian molecular clock.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Patterns of evolution in MHC class II DQA and DQB exon 2 genes of Alpine mountain hares, Lepus timidus varronis, and sympatric and parapatric brown hares, L. europaeus, from Switzerland.Immunogenetics · 2024Article
- Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice.BioMed research international · 2018Article
- Meta-populational demes constitute a reservoir for large MHC allele diversity in wild house mice (Frontiers in zoology · 2018Article
- Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.eLife · 2016Article
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
- Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing.BMC evolutionary biology · 2013Article
- Long-term balancing selection at the antiviral gene OAS1 in Central African chimpanzees.Molecular biology and evolution · 2012Article
- Characterization and evolution of MHC class II B genes in Ardeid birds.Journal of molecular evolution · 2011Article
- Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus.BMC evolutionary biology · 2011Article
- Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations.Heredity · 2011Article
- A 454 multiplex sequencing method for rapid and reliable genotyping of highly polymorphic genes in large-scale studies.BMC genomics · 2010Article
- Lineage pattern, trans-species polymorphism, and selection pressure among the major lineages of feline MHC-DRB peptide-binding region.Immunogenetics · 2010Article
- Polymorphism and signatures of selection in the multimammate rat DQB gene.Immunogenetics · 2010Article
- Extremely high MHC class I variation in a population of a long-distance migrant, the Scarlet Rosefinch (Carpodacus erythrinus).Immunogenetics · 2009Article
- Correlated evolution of nucleotide substitution rates and allelic variation in Mhc-DRB lineages of primates.BMC evolutionary biology · 2009Article
- Evolutionary history of an MHC gene in two leporid species: characterisation of Mhc-DQA in the European brown hare and comparison with the European rabbit.Immunogenetics · 2009Article
- Long-term balancing selection at the west nile virus resistance gene, Oas1b, maintains transspecific polymorphisms in the house mouse.Molecular biology and evolution · 2008Article
- Selection, diversity and evolutionary patterns of the MHC class II DAB in free-ranging Neotropical marsupials.BMC genetics · 2008Article
- Trans-species polymorphism and evidence of selection on class II MHC loci in tuco-tucos (Rodentia: Ctenomyidae).Immunogenetics · 2007Article
- Characterization, polymorphism, and evolution of MHC class II B genes in birds of prey.Journal of molecular evolution · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the evolutionary dynamics at Mhc class II DR genes of mice (genus Mus), we sequenced the peptide binding regions (PBRs) of 41 DRB (= E beta) genes and eight DRA (= E alpha) genes from 15 strains representing eight species. As expected trees of these PBR sequences imply extensive maintenance of ancestral DRB alleles across species. We use a coalescent simulation model to show that the number of interspecific coalescent events (c) observed on these trees was higher than the number expected for neutral genealogies and similar sample sizes and is more consistent with balancing selection that with neutrality. Patterns of ancestral polymorphism in mouse DRB alleles were also used to examine the tempo of synonymous substitution in the PBR of mouse class II genes. Both absolute and relative rate tests on DRA and DRB genes imply increased substitution rates at two- and fourfold degenerate sites of mice and rats relative to primates, and decreased rates for the DRB genes of primates relative to ungulate and carnivore relatives. Thus rates of synonymous substitution at Mhc DR genes in mammals appear to be subject to generation time effects in ways similar to those found at other mammalian genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.