ArticleGenetics1997
Recombination creates novel L1 (LINE-1) elements in Rattus norvegicus.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Retrotransposons and the brain: Exploring a complex relationship between mobile elements, stress, and neurological health.Neurobiology of stress · 2025Review
- Interchromosomal translocation in neural progenitor cells exposed to L1 retrotransposition.Genetics and molecular biology · 2023Article
- Organ-, sex- and age-dependent patterns of endogenous L1 mRNA expression at a single locus resolution.Nucleic acids research · 2021Article
- Early life stress during the neonatal period alters social play and Line1 during the juvenile stage of development.Scientific reports · 2021Article
- Becoming a Selfish Clan: Recombination Associated to Reverse-Transcription in LTR Retrotransposons.Genome biology and evolution · 2019Review
- Review
- Expression of genome defence protein members in proliferating and quiescent rat male germ cells and the Nuage dynamics.PloS one · 2019Article
- Contrasted patterns of evolution of the LINE-1 retrotransposon in perissodactyls: the history of a LINE-1 extinction.Mobile DNA · 2018Article
- LINE-1 retrotransposons: from 'parasite' sequences to functional elements.Journal of applied genetics · 2015Article
- Revisiting the evolution of mouse LINE-1 in the genomic era.Mobile DNA · 2013Article
- Evolutionary conservation of the functional modularity of primate and murine LINE-1 elements.PloS one · 2011Article
- Article
- Retroelements and their impact on genome evolution and functioning.Cellular and molecular life sciences : CMLS · 2009Review
- Functional endogenous LINE-1 retrotransposons are expressed and mobilized in rat chloroleukemia cells.Nucleic acids research · 2008Article
- Article
- L1 integration in a transgenic mouse model.Genome research · 2006Article
- The ORF1 protein encoded by LINE-1: structure and function during L1 retrotransposition.Journal of biomedicine & biotechnology · 2006Article
- Molecular evolution and tempo of amplification of human LINE-1 retrotransposons since the origin of primates.Genome research · 2006Article
- Multiple fates of L1 retrotransposition intermediates in cultured human cells.Molecular and cellular biology · 2005Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian L1 (long interspersed repeated DNA. LINE-1) retrotransposons consist of a 5' untranslated region (UTR) with regulatory properties, two protein encoding regions (ORF I, ORF II, which encodes a reverse transcriptase) and a 3' UTR. L1 elements have been evolving in mammals for > 100 million years and this process continues to generate novel L1 subfamilies in modern species. Here we characterized the youngest known subfamily in Rattus norvegicus, L1mlvi2, and unexpectedly found that this element has a dual ancestry. While its 3' UTR shares the same lineage as its nearest chronologically antecedent subfamilies, L13 and L14, its ORF I sequence does not. The L1mlvi2 ORF I was derived from an ancestral ORF I sequence that was the evolutionary precursor of the L13 and L14 ORF I. We suggest that an ancestral ORF I sequence was recruited into the modern L1mlvi2 subfamily by recombination that possibly could have resulted from template strand switching by the reverse transcriptase during L1 replication. This mechanism could also account for some of the structural features of rodent L1 5' UTR and ORF I sequences including one of the more dramatic features of L1 evolution in mammals, namely the repeated acquisition of novel 5' UTRs.
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