ArticleProceedings of the National Academy of Sciences of the United States of America1997
Acquisition and amplification of a testis-expressed autosomal gene, SSL, by the Drosophila Y chromosome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- TheCells · 2022Article
- Review
- Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Birth of a new gene on the Y chromosome of Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- How do y-chromosomes modulate genome-wide epigenetic States: genome folding, chromatin sinks, and gene expression.Journal of genomics · 2014Review
- Expansion and evolution of the X-linked testis specific multigene families in the melanogaster species subgroup.PloS one · 2012Article
- A large palindrome with interchromosomal gene duplications in the pericentromeric region of the D. melanogaster Y chromosome.Molecular biology and evolution · 2011Article
- Article
- Regulated chromatin domain comprising cluster of co-expressed genes in Drosophila melanogaster.Nucleic acids research · 2005Article
- Y chromosomal fertility factors kl-2 and kl-3 of Drosophila melanogaster encode dynein heavy chain polypeptides.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Paralogous stellate and Su(Ste) repeats: evolution and ability to silence a reporter gene.Genetica · 2000Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acquisition of autosomal fertility genes has been proposed to be an important process in human Y chromosome evolution. For example, the Y-linked fertility factor DAZ (Deleted in Azoospermia) appears to have arisen after the transposition and tandem amplification of the autosomal DAZH gene. The Drosophila melanogaster Y chromosome contains tandemly repeated Su(Ste) units that are thought to affect male fertility as suppressors of the homologous X-linked Stellate repeats. Here we report the detection of a testis-expressed autosomal gene, SSL [Su(Ste)-like], that appears to be an ancestor of the Y-linked Su(Ste) units. SSL encodes a casein kinase 2 (CK2) beta-subunit-like protein. Its putative ORF shares extensive (45%) homology with the genuine beta-subunit of CK2 and retains the conserved C-terminal and Glu/Asp-rich domains that are essential for CK2 holoenzyme regulation. SSL maps within region 60D1-2 of D. melanogaster and D. simulans polytene chromosomes. We present evidence that SSL was derived from the genuine betaCK2 gene by reverse transcription. This event resulted in the loss of the first three introns in the coding region of the SSL ancestor gene. Evolutionary analysis indicates that SSL has evolved under selective pressure at the translational level. Its sequence, especially in the 3' region, is much closer to the Y-linked Su(Ste) tandem repeats than to the betaCK2 gene. These results suggest that the acquisition of testis-specific autosomal genes may be important for the evolution of Drosophila as well as human Y chromosomes.
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