ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1997
Photoreceptor decay over time and apoptosis in experimental retinal detachment.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 78 citations in OpenAlex.
- Cystoid Macular Edema Following Rhegmatogenous Retinal Detachment Repair Surgery: Incidence, Pathogenesis, Risk Factors and Treatment.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- Hypoxia-Inducible Factor-1α in Rods Is Neuroprotective Following Retinal Detachment.Investigative ophthalmology & visual science · 2022Article
- Article
- Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography.Clinical ophthalmology (Auckland, N.Z.) · 2020Article
- Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells.Scientific reports · 2017Article
- Endodrainage, Tumor Photocoagulation, and Silicone Oil Tamponade for Primary Exudative Retinal Detachment due to Choroidal Melanoma Persisting after Proton Beam Therapy.Ocular oncology and pathology · 2014Article
- Scleral depressed vitreous shaving, 360 laser, and perfluoropropane (C3 F8) for retinal detachment.Indian journal of ophthalmology · 2014Article
- Inflammation and macular oedema after pars plana vitrectomy.Mediators of inflammation · 2013Review
- Safety and efficacy of intravitreal injection of recombinant erythropoietin for protection of photoreceptor cells in a rat model of retinal detachment.Eye (London, England) · 2012Article
- Photoreceptor disruption related to persistent submacular fluid after successful scleral buckle surgery.Korean journal of ophthalmology : KJO · 2011Article
- Protein changes in the retina following experimental retinal detachment in rabbits.Molecular vision · 2011Article
- Subretinal delivery of immunoglobulin G with gold nanoparticles in the rabbit eye.Japanese journal of ophthalmology · 2009Article
- Ceramide production associated with retinal apoptosis after retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Article
- Upregulation of Semaphorin 3A and the associated biochemical and cellular events in a rat model of retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Article
- High-resolution Fourier-domain optical coherence tomography and microperimetric findings after macula-off retinal detachment repair.Ophthalmology · 2008Article
- HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice.The Journal of clinical investigation · 2008Article
- Clearance of apoptotic photoreceptors: elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin alphavbeta3.The American journal of pathology · 2003Article
- Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo.The American journal of pathology · 2001Article
- Macular edema after pars plana vitrectomy for primary rhegmatogenous retinal detachment: Incidence, morphology, and risk factors.Oman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData are scarce on the actual rate and mode of outer nuclear layer decay in retinal detachment (RD). We used an experimental rabbit model to assess the presence of apoptosis and rate of photoreceptor death following RD. This model included the creation of localized and stable retinal blebs, while controlling for any decline of retinal elevation over time.
methodsRD was produced in New Zealand white rabbits by injecting 0.05 ml of 15% sodium hyaluronate (Healon GV) under the neural retina using a microsurgical technique. Animals were killed at 1, 2, 4, 7, 14 and 29 days. Retinal tissue was processed for light and electron microscopy and for in situ end labeling of fragmented DNA using a modification of the TUNEL technique. Photoreceptor cell nuclei were counted in the RD areas of maximum retinal elevation of 28 eyes, and an additional 4 eyes were used for nick end labeling.
resultsPositive DNA nick end labeling, ultrastructural features and absence of necrotic cells indicated apoptotic photoreceptor cell death. Also, there was a rapid, almost linear elimination of photoreceptor nuclei over time. At 14 days only half of the number of nuclei were discernible, while approximately one tenth remained after 29 days. There was a statistically significant, but minimal decline in RD height over the 4 weeks of study.
conclusionFollowing experimental RD in rabbits, apoptotic cell death is associated with an almost linear elimination of photoreceptor cells over time. The use of highly viscous sodium hyaluronate in separating the neural retina from the retinal pigment epithelium allows the RD to maintain a nearly constant height over a period of 4 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.