ArticleThe American journal of pathology1997
Phenotypic diversity of neoplastic chondrocytes and extracellular matrix gene expression in cartilaginous neoplasms.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Review
- The Role of IGF/IGF-IR-Signaling and Extracellular Matrix Effectors in Bone Sarcoma Pathogenesis.Cancers · 2021Review
- Selection of Effective Therapies Using Three-DimensionalFrontiers in molecular biosciences · 2020Article
- In malignant cartilagenous tumors, immunohistochemical expression of procollagen PC1CP peptide is higher and that of PC2CP lower than in benign cartilaginous lesions.Virchows Archiv : an international journal of pathology · 2015Article
- Genetic alterations in chondrosarcomas - keys to targeted therapies?Cellular oncology (Dordrecht, Netherlands) · 2014Review
- Can MR imaging challenge the commonly accepted theory of the pathogenesis of solitary enchondroma of long bone?Skeletal radiology · 2012Article
- Article
- Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?Diagnostic pathology · 2008Article
- Establishment and characterization of the permanent human cell line C3842 derived from a secondary chondrosarcoma in Ollier's disease.Virchows Archiv : an international journal of pathology · 2005Article
- Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage.Arthritis research & therapy · 2005Article
- New cell lines with chondrocytic phenotypes from human chondrosarcoma.Virchows Archiv : an international journal of pathology · 2004Article
- Chondroma of epithelial cell origin.The American journal of pathology · 2003Article
- Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development.The American journal of pathology · 2001Article
- Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas.The American journal of pathology · 2000Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chondrocyte differentiation is characterized by distinct cellular phenotypes, which can be identified by specific extracellular matrix gene expression profiles. By applying in situ analysis on the mRNA and protein level in a series of benign and malignant human chondrogenic neoplasms, we were able to identify for the first time different phenotypes of neoplastic chondrocytes in vivo: 1) mature chondrocytes, which synthesized the characteristic cartilaginous extracellular tumor matrix, 2) cells resembling hypertrophic chondrocytes of the fetal growth plate, 3) cells resembling so-called dedifferentiated chondrocytes, and 4) well differentiated chondrocytic cells, which expressed type I collagen, indicating the presence of post-hypertrophic differentiated neoplastic chondrocytes. Chondrocytes exhibiting a range of phenotypes were found to be present in the same neoplasm. The different observed phenotypes, including the dedifferentiated phenotype, were in contrast to the anaplastic cells of high-grade chondrosarcomas. Comparison of expression data with tumor morphology revealed a relationship between the cellular phenotypes, the tumor matrix composition, and the matrix and cell morphology within the neoplasms. The distinctly different phenotypes of neoplastic chondrocytes are the basis of the characteristic high biochemical and morphological heterogeneity of chondroid neoplasms and shed light on their biological and clinical behavior.
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