ArticleThe American journal of pathology1997
Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 56 citations in OpenAlex.
- ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.Developmental cell · 2011Article
- NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.Breast cancer research : BCR · 2011Article
- Article
- The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions.Clinical & experimental metastasis · 2004Article
- Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.Journal of mammary gland biology and neoplasia · 2003Review
- nm23-H1 suppresses invasion of oral squamous cell carcinoma-derived cell lines without modifying matrix metalloproteinase-2 and matrix metalloproteinase-9 expression.The American journal of pathology · 2001Article
- Role of Ets transcription factors in mammary gland development and oncogenesis.Journal of mammary gland biology and neoplasia · 2001Review
- Ets factors and regulation of the extracellular matrix.Oncogene · 2000Review
- Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter.British journal of cancer · 1999Article
- Progress in the molecular biology of ewing tumors.Sarcoma · 1998Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E1AF is a newly identified human ets-family transcription factor. We have reported that E1AF can up-regulate transcription of matrix metalloproteinase (MMP) genes and confers invasive phenotype on human cancer cells. HSC3 is an oral squamous-cell-carcinoma-derived cell line, and it manifests high levels of E1AF and MMP-1 and -9 gene expression that are associated with invasive potential. We reconstructed an E1AF antisense expression vector, transfected HSC3 cells with the vector, and obtained HSC3AS cells that express E1AF antisense RNA. HSC3AS showed decreasing mRNA and protein levels of MMP-1, -3, and -9. Moreover, HSC3AS showed lower invasive potential in vitro three-dimensional raft culture and in vivo implantation into nude mice. These results imply that transfection of antisense E1AF inhibits tumor invasion by down-regulating MMP genes.
Indexed as
Identifiers
9176403PMC1858336W231086591What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.