ArticleThe American journal of pathology1997
Steroid hormone induction and expression patterns of L-plastin in normal and carcinomatous prostate tissues.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Pooled it
- Exercise and Phellodendron amurense extract differentially impinge on oxidative stress response pathways in a mouse model of prostate cancer.Scientific reports · 2026Article
- The Dictyostelium discoideum FimA protein, unlike yeast and plant fimbrins, is regulated by calcium similar to mammalian plastins.Scientific reports · 2023Article
- Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albus.Biology of sex differences · 2022Article
- Androgen receptor modulation following combination exposure to brominated flame-retardants.Scientific reports · 2018Article
- AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin.Cell death & disease · 2017Article
- Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.Scientific reports · 2017Article
- The Calcium-Dependent Switch Helix of L-Plastin Regulates Actin Bundling.Scientific reports · 2017Article
- Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer.International journal of cell biology · 2012Article
- Analysis of the expression of biomarkers in urinary bladder cancer using a tissue microarray.Molecular carcinogenesis · 2008Article
- Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma.The American journal of pathology · 2000Article
- Suppression of prostate carcinoma cell invasion by expression of antisense L-plastin gene.The American journal of pathology · 1999Article
- Differentially expressed genes in hormone refractory prostate cancer: association with chromosomal regions involved with genetic aberrations.The American journal of pathology · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Application of differential display to the comparison of androgen-stimulated and unstimulated human prostate carcinoma cell line LNCaP identified androgen induction of the L-plastin gene, which encodes an actin-binding protein isoform. Further investigation demonstrated that L-plastin expression in LNCaP cells is up-regulated by both dihydrotestosterone and estradiol. This induction of expression is detected as early as 2 hours after addition of steroids to the cell culture. L-plastin expression is also detected in other prostate carcinoma cell lines by reverse transcriptase polymerase chain reaction and immunohistochemistry but not in the single normal adult prostate epithelial cell line that is available to us. Analysis of multiple primary prostatic tumor tissues as well as normal and tumor tissues of the same prostate gland showed that tumor tissues exhibit a higher level of expression as compared with the normal tissues. Immunohistochemical study using anti-L-plastin antiserum on normal and carcinomatous prostate tissues showed a very striking difference in the staining patterns. Positive staining was seen in the fibromuscular stroma in normal prostates but not in the glandular epithelial cells. In contrast, strong staining was seen predominantly within the carcinomatous glandular epithelial cells. Taken together, these results suggest that the expression of L-plastin in prostatic epithelial cells is linked to the malignant state and that, once expressed in carcinomas, its expression is regulated by steroid hormone receptors.
Indexed as
Identifiers
9176394PMC1858304W59165830What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.