ArticleImmunology1997
Characterization of Marek's disease herpesvirus-specific cytotoxic T lymphocytes in chickens inoculated with a non-oncogenic vaccine strain of MDV.
Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 59 citations in OpenAlex.
- Contribution of the TCRβ Repertoire to Marek's Disease Genetic Resistance in the Chicken.Viruses · 2023Article
- Marek's disease virus-specific T cells proliferate, express antiviral cytokines but have impaired degranulation response.Frontiers in immunology · 2022Article
- Differential Virus-Specific IFN-Gamma Producing T Cell Responses to Marek's Disease Virus in Chickens With B19 and B21 MHC Haplotypes.Frontiers in immunology · 2021Article
- An Anti-Tumor Vaccine Against Marek's Disease Virus Induces Differential Activation and Memory Response of γδ T Cells and CD8 T Cells in Chickens.Frontiers in immunology · 2021Article
- Depletion of CD8αβVaccines · 2020Article
- Revisiting cellular immune response to oncogenic Marek's disease virus: the rising of avian T-cell immunity.Cellular and molecular life sciences : CMLS · 2020Review
- Article
- Respiratory and GIT tract immune responses of broiler chickens following experimental infection with Newcastle disease's virus.Comparative clinical pathology · 2018Article
- Marek's disease in chickens: a review with focus on immunology.Veterinary research · 2016Review
- Clonal structure of rapid-onset MDV-driven CD4+ lymphomas and responding CD8+ T cells.PLoS pathogens · 2011Article
- Revaccination with Marek's disease vaccines induces productive infection and superior immunity.Clinical and vaccine immunology : CVI · 2009Article
- Differential cytokine responses following Marek's disease virus infection of chickens differing in resistance to Marek's disease.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously we have reported that reticuloendotheliosis virus (REV)-transformed cell lines expressing Marek's disease virus (MDV) genes pp38, meq or gB were lysed by syngeneic MDV-specific splenocytes from major histocompatibility complex (MHC):B9B19 and MHC:B1B21 chickens. In contrast, REV-transformed cell lines expressing the MDV gene ICP4 were only lysed by syngeneic MDV-specific splenocytes from MHC:B21B21 chickens. In this study we report that this syngeneic cell-mediated immune response is induced by cytotoxic T lymphocytes (CTL). Splenocytes from MDV vaccine strain, SB-1 inoculated MHC:B19B19 and MHC:B21B21 chickens, depleted for CD4+, CD8+, TCR gamma delta +, TCR alpha beta 1+ and/or TCR alpha beta 2+ cells, were used as effector cells in chromium-release assays. Effector cells depleted of CD8+ or TCR alpha beta 1+, but not TCR gamma delta + or TCR alpha beta 2+, markedly reduced the MDV-specific release. Depletion of CD4+ effector cells did not influence the specific release significantly. This is the first report on identification of virus-specific CD8+ CTL in chickens inoculated with a non-oncogenic vaccine strain of MDV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.