ArticleImmunology1997
Langerhans' cells produce type IV collagenase (MMP-9) following epicutaneous stimulation with haptens.
Article in Immunology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 82 citations in OpenAlex.
- Molecular Mechanisms of Dermal Aging and Antiaging Approaches.International journal of molecular sciences · 2019Review
- Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases.Frontiers in cell and developmental biology · 2019Review
- Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis.Cell communication and signaling : CCS · 2015Review
- Langerhans cells and their role in oral mucosal diseases.North American journal of medical sciences · 2013Review
- Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses.BMC genomics · 2010Article
- Visualizing dendritic cell migration within the skin.Histochemistry and cell biology · 2008Review
- Article
- Dendritic cells and contact dermatitis.Clinical reviews in allergy & immunology · 2007Review
- Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: a combined transcriptomic and proteomic approach.Immunology · 2001Article
- Article
- Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Protein-kinase-specific inhibitors block Langerhans' cell migration by inhibiting interleukin-1alpha release.Immunology · 1999Article
- Langerhans cells require signals from both tumour necrosis factor-alpha and interleukin-1 beta for migration.Immunology · 1997Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For initiation of the contact hypersensitivity response, epidermal Langerhans' cells (LC) migrate from the epidermis to draining nodes via afferent lymphatics by passing through the basement membrane. In this study, we examined production of matrix metalloproteinases (MMPs) in LC-enriched epidermal cells to clarify the type of enzymes involved in LC transmigration through the basement membrane. Using gelatine enzymography and immunoblotting analysis, 95,000 MW type IV collagenase (MMP-9) was found to be produced by LC-enriched epidermal cells. Analysis of the kinetics of MMP-9 expression showed that its production was induced within 6 hr after application of 2,4,6-trinitrochlorobenzene (TNCB), substantially increased between 12 hr and 24 hr, and then decreased to the normal level by 7 to 10 days. Other haptens, such as 2,4-dinitrochlorobenzene and 2,4-dinitrofluorobenzene, also induced MMP-9 expression. Fluoroescence-activated cell sorter analysis revealed that LC were one of the major cell types to express MMP-9 in response to TNCB. In addition, highly enriched LC from sensitized skin were shown to express strong gelatinolytic activity. These results indicate that LC by themselves, as well as other epidermal cells, are capable of producing MMP-9, and suggest that MMP-9 may contribute to proteolysis associated with transmigration of LC in the induction phase of contact dermatitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.