ArticleImmunity1997
CD8 lineage commitment in the absence of CD8.
Article in Immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- T-cell virtuosity in ''knowing thyself".Frontiers in immunology · 2024Review
- A TCR mechanotransduction signaling loop induces negative selection in the thymus.Nature immunology · 2018Article
- Duality of the murine CD8 compartment.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- How the TCR balances sensitivity and specificity for the recognition of self and pathogens.Nature immunology · 2012Review
- Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.Journal of virology · 2012Article
- MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency.Haematologica · 2011Article
- Development of thymically derived natural regulatory T cells.Annals of the New York Academy of Sciences · 2010Review
- A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.Science (New York, N.Y.) · 2009Article
- Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.Nature reviews. Immunology · 2009Review
- The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.European journal of immunology · 2008Article
- Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors.Journal of virology · 2008Article
- A constant affinity threshold for T cell tolerance.The Journal of experimental medicine · 2007Article
- On the logic of positive selection.Immunology · 2006Review
- Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta.Journal of virology · 2005Article
- Natural killer cells play a critical role in the immune response following immunization with melanoma-antigen-engineered dendritic cells.Cancer gene therapy · 2005Article
- An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4.The Journal of experimental medicine · 2005Article
- CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes.The Journal of experimental medicine · 2001Article
- Familial CD8 deficiency due to a mutation in the CD8 alpha gene.The Journal of clinical investigation · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8alpha-deficient mice can restore positive selection of CD8 lineage cells in the absence of CD8. The positively selected cells down-regulate CD4, up-regulate TCR, respond to the antigenic peptide, and express CD8beta mRNA. Interestingly, there was no enhanced selection of CD4+ T cells, implying that the TCR-MHC interaction, even in the absence of CD8, provided instructive signaling for commitment to the CD8 lineage. Our results are discussed in terms of recent models of T cell lineage commitment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.