ArticleThe Journal of physiology1997
Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- TRPM2-mediated CaCell communication and signaling : CCS · 2023Review
- Review
- Hydrogen Peroxide Gates a Voltage-Dependent Cation Current inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation.Journal of cellular physiology · 2019Article
- Transient Receptor Potential-Melastatin Channel Family Member 2: Friend or Foe.Transactions of the American Clinical and Climatological Association · 2017Review
- TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death.Neuroscience letters · 2012Article
- Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- TRPM2: a multifunctional ion channel for calcium signalling.The Journal of physiology · 2011Review
- Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and KFrontiers in systems neuroscience · 2011Article
- Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death.The Journal of biological chemistry · 2010Article
- Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity.The Journal of general physiology · 2009Article
- Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils.Cell calcium · 2008Article
- Regulation of TRPM2 by extra- and intracellular calcium.The Journal of general physiology · 2007Article
- The role of TRPM channels in cell death.Pflugers Archiv : European journal of physiology · 2005Review
- TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.Pflugers Archiv : European journal of physiology · 2005Review
- Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel.The Journal of physiology · 2003Article
- Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD).The Journal of physiology · 2001Review
- Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells.The Biochemical journal · 2000Article
- Interference of H2O2 with stimulus-secretion coupling in mouse pancreatic beta-cells.The Journal of physiology · 1999Article
- Reduced glutathione inhibits beta-NAD+-activated non-selective cation currents in the CRI-G1 rat insulin-secreting cell line.The Journal of physiology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a non-selective cation channel. The channel opened is characterized by a linear current-voltage relation with a conductance of approximately 70 pS and very slow kinetics (of the order of seconds). 2. Cells are protected against the alloxan-induced channel opening and consequent cell depolarization by the presence of H2O2 and hydroxyl radical scavengers. 3. The free radical-activated non-selective cation channel is not operative in isolated patches but can be activated by the application of beta-NAD+ to the cytoplasmic aspect of the membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.