ArticleClinical & experimental metastasis1997
Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23).
Article in Clinical & experimental metastasis, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Metastasis suppressors: functional pathways.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Metastasis suppressor genes.Histology and histopathology · 2013Review
- Genomics screens for metastasis genes.Cancer metastasis reviews · 2012Review
- Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene.Cancer metastasis reviews · 2012Review
- Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer.Journal of the National Cancer Institute · 2012Article
- Altered gene and protein expression by Nm23-H1 in metastasis suppression.Molecular and cellular biochemistry · 2009Review
- Nm23-H1 homologs suppress tumor cell motility and anchorage independent growth.Clinical & experimental metastasis · 2008Article
- Translational approaches using metastasis suppressor genes.Journal of bioenergetics and biomembranes · 2006Review
- Inhibition of ovarian cancer metastasis by adeno-associated virus-mediated gene transfer of nm23H1 in an orthotopic implantation model.Cancer gene therapy · 2006Article
- Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells.Molecular and cellular biology · 2005Article
- Article
- Basic and translational advances in cancer metastasis: Nm23.Journal of bioenergetics and biomembranes · 2003Review
- Inhibition of signal transduction by the nm23 metastasis suppressor: possible mechanisms.Clinical & experimental metastasis · 2003Review
- Chromosomal aberrations related to metastasis of human solid tumors.World journal of gastroenterology · 2002Review
- MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines.Clinical & experimental metastasis · 2002Article
- Nm23/nucleoside diphosphate kinase in human cancers.Journal of bioenergetics and biomembranes · 2000Review
- The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines.Clinical & experimental metastasis · 2000Article
- In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- The role of metastasis suppressor genes in metastatic dormancy.APMIS : acta pathologica, microbiologica, et immunologica ScandinavicaReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Metastasis is suppressed more than 95% following microcell-mediated transfer of a single copy of neomycin-tagged human chromosome 6 (neo6) into the human melanoma cell lines C8161 and MelJuSo. Concomitant with metastasis suppression is upregulation of NME1 (Nm23-H1) mRNA and protein expression. The purposes of this study were to determine whether NME1 expression was responsible for metastasis suppression in neo6/melanoma hybrids, and whether genes on chromosome 6 regulate NME1. Using neo6/C8161 cells, transfection of CAT reporter constructs linked to the NME1 promoter failed to consistently induce CAT. Therefore, it does not appear that genes on chromosome 6 directly control transcription of NME1. Transfection and overexpression of NME1 in MelJuSo, under the control of the CMV promoter, resulted in 40-80% inhibition of lung metastasis following i.v. inoculation of 2 x 10(5) cells. Only one transfectant of C8161 subclone 9 (C8161cl.9) cells was suppressed for metastasis. Control transfections with pCMVneo or pSV2neo did not suppress metastasis in either cell line. Taken together, these data suggest that NME1 can reduce metastatic potential of some human melanoma cells; but, this inhibitory activity appears to be independent of the metastasis suppression following introduction of chromosome 6 into C8161 and MelJuSo human melanoma cell lines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.