ArticleNucleic acids research1997
The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 127 citations in OpenAlex.
- The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm?Protein science : a publication of the Protein Society · 2024Article
- Structural aspects of the MHC expression control system.Biophysical chemistry · 2022Review
- The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins.International journal of molecular sciences · 2021Review
- Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition.Journal for immunotherapy of cancer · 2019Article
- Article
- Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo.European journal of immunology · 2017Article
- Article
- Comparison of immunological characteristics of mesenchymal stem cells derived from human embryonic stem cells and bone marrow.Tissue engineering. Part A · 2015Article
- CIITA and Its Dual Roles in MHC Gene Transcription.Frontiers in immunology · 2013Article
- Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements.Nucleic acids research · 2013Article
- Role of Sug1, a 19S proteasome ATPase, in the transcription of MHC I and the atypical MHC II molecules, HLA-DM and HLA-DO.Immunology letters · 2012Article
- Article
- Novel functions for TAF7, a regulator of TAF1-independent transcription.The Journal of biological chemistry · 2010Article
- Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies.Molecular and cellular biology · 2010Article
- The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.Journal of molecular biology · 2007Article
- ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.Molecular immunology · 2007Article
- Transcriptional regulation by Modulo integrates meiosis and spermatid differentiation in male germ line.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.Journal of virology · 2005Article
- Article
- Splicing defect in RFXANK results in a moderate combined immunodeficiency and long-duration clinical course.Immunogenetics · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The class II trans- activator (CIITA) is the main transcriptional co-activator for the expression of MHC class II proteins. Its N-terminal 125 amino acids function as an independent transcriptional activation domain. Analyses of the primary amino acid sequence of the activation domain predict the presence of three alpha-helices, each with a high proportion of acidic residues. Using site-directed mutagenesis, we found that two of these predicted alpha-helices are required for full transcriptional activation by CIITA. Moreover, a CIITA protein in which both functional alpha-helices have been deleted displays a dominant negative phenotype. This activation domain of CIITA interacts with the 32 kDa subunit of the general transcription complex TFIID, TAFII32. Decreased transcriptional activation by N-terminal deletions of CIITA is correlated directly with their reduced binding to TAFII32. We conclude that interactions between TAFII32 and CIITA are responsible for activation of class II genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.