ArticleInfection and immunity1997
Identification and characterization of a DNA region involved in the export of capsular polysaccharide by Actinobacillus pleuropneumoniae serotype 5a.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Article
- The two-component system CpxA/CpxR is critical for full virulence inFrontiers in microbiology · 2022Article
- Chemical structure and genetic organization of the E. coli O6:K15 capsular polysaccharide.Scientific reports · 2020Article
- Surface Polysaccharide Mutants Reveal that Absence of O Antigen Reduces Biofilm Formation of Actinobacillus pleuropneumoniae.Infection and immunity · 2016Article
- Identification of conserved surface proteins as novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae.Journal of microbiology (Seoul, Korea) · 2012Article
- Article
- ABC transporters involved in export of cell surface glycoconjugates.Microbiology and molecular biology reviews : MMBR · 2010Review
- Multiplex PCR that can distinguish between immunologically cross- reactive serovar 3, 6, and 8 Actinobacillus pleuropneumoniae strains.Journal of clinical microbiology · 2008Article
- Identification of the Actinobacillus pleuropneumoniae leucine-responsive regulatory protein and its involvement in the regulation of in vivo-induced genes.Infection and immunity · 2007Article
- Lipoprotein PssN of Rhizobium leguminosarum bv. trifolii: subcellular localization and possible involvement in exopolysaccharide export.Journal of bacteriology · 2006Article
- Detection and identification of Actinobacillus pleuropneumoniae serotypes 1, 2, and 8 by multiplex PCR.Journal of clinical microbiology · 2004Article
- Surface polysaccharides and iron-uptake systems of Actinobacillus pleuropneumoniae.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2004Review
- Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host.Infection and immunity · 2003Article
- Association of Actinobacillus pleuropneumoniae capsular polysaccharide with virulence in pigs.Infection and immunity · 2003Article
- Analysis of the capsule biosynthetic locus of Mannheimia (Pasteurella) haemolytica A1 and proposal of a nomenclature system.Infection and immunity · 2001Article
- Molecular cloning and mutagenesis of a DNA locus involved in lipooligosaccharide biosynthesis in Haemophilus somnus.Infection and immunity · 2000Article
- Cloning and mutagenesis of a serotype-specific DNA region involved in encapsulation and virulence of Actinobacillus pleuropneumoniae serotype 5a: concomitant expression of serotype 5a and 1 capsular polysaccharides in recombinant A. pleuropneumoniae serotype 1.Infection and immunity · 1998Article
- Detection and identification of Actinobacillus pleuropneumoniae serotype 5 by multiplex PCR.Journal of clinical microbiology · 1998Article
- Phase variation and conservation of lipooligosaccharide epitopes in Haemophilus somnus.Infection and immunity · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actinobacillus pleuropneumoniae synthesizes a serotype-specific capsular polysaccharide that acts as a protective barrier to phagocytosis and complement-mediated killing. To begin understanding the role of A. pleuropneumoniae capsule in virulence, we sought to identify the genes involved in capsular polysaccharide export and biosynthesis. A 5.3-kb XbaI fragment of A. pleuropneumoniae serotype 5a J45 genomic DNA that hybridized with DNA probes specific for the Haemophilus influenzae type b cap export region was cloned and sequenced. This A. pleuropneumoniae DNA fragment encoded four open reading frames, designated cpxDCBA. The nucleotide and predicted amino acid sequences of cpxDCBA contained a high degree of homology to the capsule export genes of H. influenzae type b bexDCBA, Neisseria meningitidis group B ctrABCD, and, to a lesser extent, Escherichia coli K1 and K5 kpsE and kpsMT. When present in trans, the cpxDCBA gene cluster complemented kpsM::TnphoA or kpsT::TnphoA mutations, determined by enzyme immunoassay and by restored sensitivity to a K5-specific bacteriophage. A cpxCB probe hybridized to genomic DNA from all A. pleuropneumoniae serotypes tested, indicating that this DNA was conserved among serotypes. These data suggest that A. pleuropneumoniae produces a group II family capsule similar to those of related mucosal pathogens.
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