ArticleInfection and immunity1997
Environmental regulation of fimbrial gene expression in Porphyromonas gingivalis.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Nutritional pressure from serum amplifies dysbiotic features in an oral microbiome synthetic community.The ISME journal · 2026Article
- The Impact of Serum on a Complex Synthetic Community Model of the Subgingival Microbiome.bioRxiv : the preprint server for biology · 2025Article
- Periodontopathogen-Related Cell Autophagy-A Double-Edged Sword.Inflammation · 2025Review
- Selective activation of TGFβ signaling byAmerican journal of cancer research · 2023Article
- Dendritic cells a critical link to alveolar bone loss and systemic disease risk in periodontitis: Immunotherapeutic implications.Periodontology 2000 · 2022Review
- A Tale of Two Fimbriae: How Invasion of Dendritic Cells byPathogens (Basel, Switzerland) · 2022Review
- Interaction Between Autophagy andFrontiers in cellular and infection microbiology · 2022Review
- Host and bacterial factors linking periodontitis and rheumatoid arthritis.Frontiers in immunology · 2022Review
- Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update.Journal of oral microbiology · 2020Review
- Role of FAD-I in Fusobacterial Interspecies Interaction and Biofilm Formation.Microorganisms · 2020Article
- PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.BMC microbiology · 2019Article
- Polymicrobial synergy within oral biofilm promotes invasion of dendritic cells and survival of consortia members.NPJ biofilms and microbiomes · 2019Article
- [Research advances on the molecular mechanism of autophagy regulated by Porphyromonas gingivalis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Review
- A novel peptidic inhibitor derived from Streptococcus cristatus ArcA attenuates virulence potential of Porphyromonas gingivalis.Scientific reports · 2017Article
- High-throughput sequencing reveals key genes and immune homeostatic pathways activated in myeloid dendritic cells by Porphyromonas gingivalis 381 and its fimbrial mutants.Molecular oral microbiology · 2016Article
- Dendritic cells: microbial clearance via autophagy and potential immunobiological consequences for periodontal disease.Periodontology 2000 · 2015Review
- Porphyromonas gingivalis evasion of autophagy and intracellular killing by human myeloid dendritic cells involves DC-SIGN-TLR2 crosstalk.PLoS pathogens · 2015Article
- Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis.Virulence · 2015Review
- Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors.Molecular oral microbiology · 2014Article
- Identification of a diguanylate cyclase and its role in Porphyromonas gingivalis virulence.Infection and immunity · 2014Article
Corrections and comments
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3 authors.
Funding
Abstract
Porphyromonas gingivalis fimbriae are an important virulence factor involved in attachment and invasion. Fimbrillin, encoded by the fimA gene, is the major subunit protein of the fimbriae. To elucidate the influence of environmental signals on the expression of the fimA gene, a strain of P. gingivalis (designated PLE) containing a chromosomal transcriptional fusion between a promoterless lacZ gene and the fimA promoter region was constructed. Promoter activity was assessed by measurement of beta-galactosidase activity of PLE. An 11-fold increase in activity of fimA promoter was found as growth temperature declined from 39 to 34 degrees C. Promoter activity decreased by approximately 50% in response to hemin limitation and upon culture on solid medium. In addition, the presence of serum or saliva in the growth medium decreased fimA promoter activity by similar amounts. A correlation between fimA promoter activity and phenotypic properties dependent upon fimbriae was established. P. gingivalis grown at 34 degrees C, compared to 39 degrees C, showed an increased ability to adhere to Streptococcus gordonii and to invade primary cultures of gingival epithelial cells. These studies indicate that expression of the P. gingivalis fimA gene is regulated at the transcriptional level in response to several environmental conditions and that altered fimA expression can also modulate the adherence and invasion abilities of P. gingivalis.
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