ArticleInfection and immunity1997
Reactivation of chlamydial genital tract infection in mice.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Invariant and Diverse NKT Cells Regulate Bacterial Clearance and Pathology in Chlamydial Genital Tract Infection in Mice.Pathogens (Basel, Switzerland) · 2025Article
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- Human genetic diversity regulating theHGG advances · 2022Article
- Article
- Genomic variant representation in a Chlamydia population is dynamic and adaptive with dependence on in vitro and in vivo passage.Pathogens and disease · 2015Article
- Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.Journal of bacteriology · 2014Article
- Plasmid CDS5 influences infectivity and virulence in a mouse model of Chlamydia trachomatis urogenital infection.Infection and immunity · 2014Article
- Induction of the Chlamydia muridarum stress/persistence response increases azithromycin treatment failure in a murine model of infection.Antimicrobial agents and chemotherapy · 2014Article
- Laboratory diagnosis of persistent human chlamydial infection.Frontiers in cellular and infection microbiology · 2013Review
- Regulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles.Infection and immunity · 2011Article
- Strain and virulence diversity in the mouse pathogen Chlamydia muridarum.Infection and immunity · 2009Article
- Outcome of urogenital infection with Chlamydia muridarum in CD14 gene knockout mice.BMC infectious diseases · 2006Article
- Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice.Infection and immunity · 2005Article
- Amplification of autoimmune disease by infection.Arthritis research & therapy · 2005Review
- The infecting dose of Chlamydia muridarum modulates the innate immune response and ascending infection.Infection and immunity · 2004Article
- Inducible nitric oxide synthase regulates production of isoprostanes in vivo during chlamydial genital infection in mice.Infection and immunity · 2003Article
- Characterization of chlamydial genital infection resulting from sexual transmission from male to female guinea pigs and determination of infectious dose.Infection and immunity · 2003Article
- Chlamydia trachomatis disrupts N-cadherin-dependent cell-cell junctions and sequesters beta-catenin in human cervical epithelial cells.Infection and immunity · 2002Article
- Role for inducible nitric oxide synthase in protection from chronic Chlamydia trachomatis urogenital disease in mice and its regulation by oxygen free radicals.Infection and immunity · 2001Article
- Chlamydia trachomatis persistence in the female mouse genital tract: inducible nitric oxide synthase and infection outcome.Infection and immunity · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A model was developed to study chlamydial quiescence in C3H/HeN (C3H) and C57BL/6N (C57) mice following genital tract infection by Chlamydia trachomatis MoPn. Reactivation of chlamydial shedding following immunosuppression indicated that viable MoPn remained in the genital tract for up to 4 or 5 weeks after the apparent clearance of a primary infection. Either cyclophosphamide or cortisone acetate treatment could cause reactivation, but cyclophosphamide was more effective. However, the frequency of reactivation by either drug diminished with time in both mouse strains. Progesterone treatment prior to infection of C57 mice greatly reduced the frequency of reactivation by cyclophosphamide and also correlated with the development of marked fluid accumulation and distension of the uterine horns in the vast majority of those animals. This pathology was apparent by 5 to 7 weeks postinfection and was consistently seen through 110 days postinfection. Neither of these phenomena was observed in C57 mice that had not been treated with progesterone or in C3H mice under any conditions tested. The infecting dose of MoPn did not clearly influence the frequency of reactivation in either inbred strain as defined by this model.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.