ArticleInfection and immunity1997
Characterization of an antigen from Leishmania amazonensis amastigotes able to elicit protective responses in a murine model.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Use of a recombinant cysteine proteinase from Leishmania (Leishmania) infantum chagasi for the Immunotherapy of canine visceral Leishmaniasis.PLoS neglected tropical diseases · 2014Trial
- Roles of Cysteine Proteases in Biology and Pathogenesis of Parasites.Microorganisms · 2023Article
- Review
- Proteins of Leishmania (Viannia) shawi confer protection associated with Th1 immune response and memory generation.Parasites & vectors · 2012Article
- Computational analysis of cysteine proteases (Clan CA, Family Cl) of Leishmania major to find potential epitopic regions.Genomics, proteomics & bioinformatics · 2009Article
- Identification and molecular characterization of a gene encoding a protective Leishmania amazonensis Trp-Asp (WD) protein.Infection and immunity · 2004Article
- Ultrastructural and cytochemical identification of megasome in Leishmania (Leishmania) chagasi.Parasitology research · 2004Article
- DNA immunization with the gene encoding P4 nuclease of Leishmania amazonensis protects mice against cutaneous Leishmaniasis.Infection and immunity · 2003Article
- Characterization of Leishmania donovani antigens encapsulated in liposomes that induce protective immunity in BALB/c mice.Infection and immunity · 2002Article
- Essential role of platelet-activating factor in control of Leishmania (Leishmania) amazonensis infection.Infection and immunity · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymphoproliferative responses to an antigen from Leishmania amazonensis amastigotes with an apparent molecular mass of 30 kDa, termed p30, were evaluated with BALB/c mice. The p30 antigen was purified after separation of parasite extracts by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by electroelution. Lymphoproliferative responses to p30 were obtained by subcutaneous immunization of animals with L. amazonensis amastigote extracts, and maximal stimulation indices were observed at an antigen concentration of 5 microg/ml. Induction of lymphoproliferation by p30 is stage specific, and no differences in the responses to this antigen between mice susceptible and resistant to L. amazonensis were detected. The predominant T cells characterized in the lymphocyte cultures were CD4+. Lymphokine analysis of the supernatants from these cultures indicated that Th1 is the subset involved in the lymphoproliferative responses to the antigen. BALB/c mice immunized with p30 and challenged with L. amazonensis amastigotes showed a very low level of infection, indicating a protective role for p30 and a correlation between Th1 and protection. Further biochemical characterization studies showed that this antigen presents cysteine proteinase activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.