ArticleThe Biochemical journal1997
Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stress.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 157 citations in OpenAlex.
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- The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish.PLoS genetics · 2025Article
- Acquired Glucose-6-Phosphate Dehydrogenase Deficiency.Journal of clinical medicine · 2022Review
- A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic acid) Isolated from Burdock Leaf Up-Regulates Cells' Oxidative Stress Defense Pathway.Antioxidants (Basel, Switzerland) · 2021Article
- Redox Signaling in Neurotransmission and Cognition During Aging.Antioxidants & redox signaling · 2018Review
- Interplay between oxidant species and energy metabolism.Redox biology · 2016Review
- Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.Archives of toxicology · 2016Article
- HSPB1 Enhances SIRT2-Mediated G6PD Activation and Promotes Glioma Cell Proliferation.PloS one · 2016Article
- Effect of linear alkylbenzene mixtures and sanitary sewage in biochemical and molecular responses in pacific oyster Crassostrea gigas.Environmental science and pollution research international · 2015Article
- Cross-omics comparison of stress responses in mesothelial cells exposed to heat- versus filter-sterilized peritoneal dialysis fluids.BioMed research international · 2015Article
- Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.Neoplasia (New York, N.Y.) · 2014Article
- Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease.Experimental neurology · 2014Article
- Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.The EMBO journal · 2014Article
- Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease.Neurobiology of aging · 2014Article
- A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation.Cell cycle (Georgetown, Tex.) · 2013Article
- Glucose-6-phosphate dehydrogenase plays a pivotal role in tolerance to drought stress in soybean roots.Plant cell reports · 2013Article
- Interactions of NADP-reducing enzymes across varying environmental conditions: a model of biological complexity.G3 (Bethesda, Md.) · 2012Article
- Phenylpyruvic acid decreases glucose-6-phosphate dehydrogenase activity in rat brain.Cellular and molecular neurobiology · 2012Article
- NADPH regulates human NAD kinase, a NADP⁺-biosynthetic enzyme.Molecular and cellular biochemistry · 2011Article
- Multiple transcripts encode glucose 6-phosphate dehydrogenase in the southern cattle tick, Rhipicephalus (Boophilus) microplus.Experimental & applied acarology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports have demonstrated that glucose-6-phosphate dehydrogenase (G6PD) activity in mammalian cells is necessary in order to ensure cell survival when damage is produced by reactive oxygen intermediates. In this paper we demonstrate that oxidative stress, caused by agents acting at different steps in the biochemical pathway controlling the intracellular redox status, determines the increase in G6PD-specific activity in human cell lines of different tissue origins. The intracellular level of G6PD-specific mRNA also increases, with kinetics compatible with the induction of new enzyme synthesis. We carried out experiments in which cells were exposed to oxidative stress in the presence of inhibitors of protein or RNA synthesis. These demonstrated that increased G6PD expression is mainly due to an increased rate of transcription, with a minor but significant contribution of regulatory mechanisms acting at post-transcriptional levels. These results provide new information on the defence systems that eukaryotic cells possess in order to prevent damage caused by potentially harmful oxygen derivatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.