ArticleThe Journal of clinical investigation1997
EGF receptor activation stimulates endogenous gastrin gene expression in canine G cells and human gastric cell cultures.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Extracellular signalling regulates gastrin transcription through site-specific phosphorylation and nuclear redistribution of Menin.bioRxiv : the preprint server for biology · 2026Article
- Clinically Defined Mutations inCancer research communications · 2023Article
- Gastrin: From Physiology to Gastrointestinal Malignancies.Function (Oxford, England) · 2022Review
- DOK6 promoter methylation serves as a potential biomarker affecting prognosis in de novo acute myeloid leukemia.Cancer medicine · 2019Article
- Article
- Chromosomal breaks at FRA18C: association with reducedNPJ precision oncology · 2017Article
- UNC50 prompts G1/S transition and proliferation in HCC by regulation of epidermal growth factor receptor trafficking.PloS one · 2015Article
- Article
- Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF).Endocrinology · 2012Article
- Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.PloS one · 2012Article
- Helicobacter pylori induction of the gastrin promoter through GC-rich DNA elements.Helicobacter · 2010Article
- Somatostatin stimulates menin gene expression by inhibiting protein kinase A.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Epidermal growth factor increases the interaction between nucleolin and heterogeneous nuclear ribonucleoprotein K/poly(C) binding protein 1 complex to regulate the gastrin mRNA turnover.Molecular biology of the cell · 2007Article
- The Epstein-Barr virus protein BMRF1 activates gastrin transcription.Journal of virology · 2005Article
- Article
- Gastrin, somatostatin, G and D cells of gastric ulcer in rats.World journal of gastroenterology · 2002Article
- An OmpA-like protein from Acinetobacter spp. stimulates gastrin and interleukin-8 promoters.Infection and immunity · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Gastrin release from the antral gastrin-expressing cell (G cell) is regulated by bombesin and luminal factors. Yet, these same extracellular regulators do not stimulate expression of the gene. Since the gastric mucosa expresses large quantities of EGF receptor ligands such as TGFalpha, we examined whether EGF receptor ligands stimulate gastrin gene expression in gastrin-expressing cell cultures. EGF receptor activation of primary cultures stimulated gastrin gene expression about twofold; whereas bombesin treatment of antral G cell cultures stimulated gastrin release but not gene expression. EGF and TGFalpha were weak stimulants of gastrin release. EGF receptor activation of AGS human gastric adenocarcinoma cell line stimulated gastrin gene expression nearly fourfold; and gastrin reporter constructs transfected into AGS cells were stimulated more than fourfold by EGF. EGF induction was conferred by the previously defined GC-rich gastrin EGF response element (gERE) element located at -68 to -53 bp upstream from the cap site since a mutation of the gERE element abolished both basal and EGF induction. Moreover, EGF treatment of AGS cells stimulated binding of the transcription factor Sp1 to this element. Collectively, these results demonstrate that gastrin gene expression and gastrin release are regulated by different signaling pathways: gene expression by EGF receptor activation and gastrin secretion by neuropeptides and luminal factors.
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