ArticleBiophysical journal1997
Two-dimensional components and hidden dependencies provide insight into ion channel gating mechanisms.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Markov models and long-term memory in ion channels: A contradiction in terms?Biophysical journal · 2025Article
- Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch.The Journal of general physiology · 2023Article
- Molecular mechanism of BK channel activation by the smooth muscle relaxant NS11021.The Journal of general physiology · 2020Article
- High-speed AFM reveals accelerated binding of agitoxin-2 to a KScience advances · 2019Article
- Structural basis for gating the high-conductance CaNature · 2017Article
- Single-channel kinetics of BK (Slo1) channels.Frontiers in physiology · 2014Review
- Exponential sum-fitting of dwell-time distributions without specifying starting parameters.Biophysical journal · 2013Article
- Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors.The Journal of biological chemistry · 2012Article
- Voltage- and cold-dependent gating of single TRPM8 ion channels.The Journal of general physiology · 2011Article
- Voltage-dependent inactivation gating at the selectivity filter of the MthK K+ channel.The Journal of general physiology · 2010Article
- Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.The Journal of general physiology · 2010Article
- Intracellular Mg2+ influences both open and closed times of a native Ca2+-activated BK channel in cultured human renal proximal tubule cells.The Journal of membrane biology · 2005Article
- Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels.The Journal of general physiology · 2001Article
- Two-dimensional kinetic analysis suggests nonsequential gating of mechanosensitive channels in Xenopus oocytes.Biophysical journal · 2001Article
- Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels.Biophysical journal · 2000Article
- Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms.Biophysical journal · 2000Article
- Gating kinetics of single large-conductance Ca2+-activated K+ channels in high Ca2+ suggest a two-tiered allosteric gating mechanism.The Journal of general physiology · 1999Article
- Opening mechanism of a cyclic nucleotide-gated channel based on analysis of single channels locked in each liganded state.The Journal of general physiology · 1999Article
- Non-markovian gating of ca(2+)-activated k(+) channels in cultured kidney cells vero. Rescaled range analysis.Journal of biological physics · 1999Article
- Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel.Biophysical journal · 1999Article
Corrections and comments
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3 authors.
Funding
Abstract
Correlations between the durations of adjacent open and shut intervals recorded from ion channels contain information about the underlying gating mechanism. This study presents an additional approach to extracting the correlation information. Detailed correlation information is obtained directly from single-channel data and quantified in a manner that can provide insight into the connections among the states underlying the gating. The information is obtained independently of any specific kinetic scheme, except for the general assumption of Markov gating. The durations of adjacent open and shut intervals are binned into two-dimensional (2-D) dwell-time distributions. The 2-D (joint) distributions are fitted with sums of 2-D exponential components to determine the number of 2-D components, their volumes, and their open and closed time constants. The dependency of each 2-D component is calculated by comparing its observed volume to the volume that would be expected if open and shut intervals paired independently. The estimated component dependencies are then used to suggest gating mechanisms and to provide a powerful means of examining whether proposed gating mechanisms have the correct connections among states. The sensitivity of the 2-D method can identify hidden components and dependencies that can go undetected by previous correlation methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.