ArticleBiophysical journal1997
Role of S4 segments and the leucine heptad motif in the activation of an L-type calcium channel.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- The distinct role of the four voltage sensors of the skeletal CaV1.1 channel in voltage-dependent activation.The Journal of general physiology · 2021Article
- CaChannels (Austin, Tex.) · 2020Review
- Zn2+-induced changes in Cav2.3 channel function: An electrophysiological and modeling study.The Journal of general physiology · 2020Article
- Calcium channel gating.Pflugers Archiv : European journal of physiology · 2018Review
- Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels.Structure (London, England : 1993) · 2016Article
- Functional heterogeneity of the four voltage sensors of a human L-type calcium channel.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Impaired gating of an L-Type Ca(2+) channel carrying a mutation linked to malignant hyperthermia.Biophysical journal · 2013Article
- Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain.Journal of neurophysiology · 2009Article
- The effect of the outermost basic residues in the S4 segments of the Ca(V)3.1 T-type calcium channel on channel gating.Pflugers Archiv : European journal of physiology · 2007Article
- Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorder.The Journal of biological chemistry · 2005Article
- Molecular regions underlying the activation of low- and high-voltage activating calcium channels.European biophysics journal : EBJ · 2005Article
- Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels.Pflugers Archiv : European journal of physiology · 2005Article
- Involvement of a heptad repeat in the carboxyl terminus of the dihydropyridine receptor beta1a subunit in the mechanism of excitation-contraction coupling in skeletal muscle.Biophysical journal · 2004Article
- Truncation of the carboxyl terminus of the dihydropyridine receptor beta1a subunit promotes Ca2+ dependent excitation-contraction coupling in skeletal myotubes.Biophysical journal · 2003Article
- The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans.The Journal of cell biology · 2002Article
- Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Effects of mutations causing hypokalaemic periodic paralysis on the skeletal muscle L-type Ca2+ channel expressed in Xenopus laevis oocytes.The Journal of physiology · 1999Article
- Role of calcium permeation in dihydropyridine receptor function. Insights into channel gating and excitation-contraction coupling.The Journal of general physiology · 1999Article
- Critical role of conserved proline residues in the transmembrane segment 4 voltage sensor function and in the gating of L-type calcium channels.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Gating of the L-type Ca channel in human skeletal myotubes: an activation defect caused by the hypokalemic periodic paralysis mutation R528H.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Basic residues in the S4 segments of voltage-dependent channels and leucines within the heptad repeat motif in the S4-S5 region of Shaker potassium channels have been shown to have important influences on activation. Here we have compared the relative importance for activation of S4 arginines (mutated to neutral or negative residues) in each of the four repeats of a chimeric L-type calcium channel. Significant effects on midpoint potential and time constant of activation were produced by mutations in repeats I and III but not in repeats II and IV. Leucine or isoleucine mutations in repeats I and III had the same effect on the voltage dependence of calcium channel activation as the mutations at equivalent positions in the Shaker channel, indicating that the heptad motif plays a fundamental role in channel activation.
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