ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 35 citations in OpenAlex.
- Banana breeding by genome design.Journal of integrative plant biology · 2025Review
- Why Do Some Vertebrates Have Microchromosomes?Cells · 2021Review
- Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens.Trends in immunology · 2018Review
- Primordial linkage of β2-microglobulin to the MHC.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- A consensus linkage map of the chicken genome.Genome research · 2000Article
- A chromosome-based model for estimating the number of conserved segments between pairs of species from comparative genetic maps.Genetics · 2000Article
- Chicken microchromosomes are hyperacetylated, early replicating, and gene rich.Genome research · 1998Article
- Mapping of FASN and ACACA on two chicken microchromosomes disrupts the human 17q syntenic group well conserved in mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
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4 authors at 1 institution in 1 country.
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Abstract
The genes for insulin-like growth factor 1 receptor (IGF1R), aggrecan (AGC1), beta2-microglobulin (B2M), and an H6-related gene have been mapped to a single chicken microchromosome by genetic linkage analysis. In addition, a second H6-related gene was mapped to chicken macrochromosome 3. The Igf1r and Agc1 loci are syntenic on mouse Chr 7, together with Hmx3, an H6-like locus. This suggests that the H6-related locus, which maps to the chicken microchromosome in this study, is the homolog of mouse Hmx3. The IGF1R, AGC1, and B2M loci are located on human Chr 15, probably in the same order as found for this chicken microchromosome. This conserved segment, however, is not entirely conserved in the mouse and is split between Chr 7 (Igf1r-Agc) and 2 (B2m). This comparison also predicts that the HMX3 locus may map to the short arm of human Chr 15. The conserved segment defined by the IGF1R-AGC1-HMX3-B2M loci is approximately 21-35 Mb in length and probably covers the entire chicken microchromosome. These results suggest that a segment of human Chr 15 has been conserved as a chicken microchromosome. The significance of this result is discussed with reference to the evolution of the avian and mammalian genomes.
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