ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
The mouse Cat4 locus maps to chromosome 8 and mutants express lens-corneal adhesion.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Mouse models of cataract.Journal of genetics · 2009Review
- Article
- Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival.Developmental biology · 2009Article
- Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus.Genetics · 2008Article
- Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Cat4 is the second largest allelism group in the collection of mouse dominant eye mutations recovered in Neuherberg and carriers express anterior polar cataract, central corneal opacity, and lens-corneal adhesions. We have mapped the Cat4 locus of the mouse to central Chromosome (Chr) 8 at position cM 31. Histological characterization of Cat4(a) heterozygotes and homozygotes indicates failure of separation of the lens vesicle from the surface ectoderm. Human anterior segment ocular dysgenesis (ASOD) is autosomal dominant, carriers express an eye phenotype similar to that of Cat4(a) carriers, and it has been mapped to a region of 4q homologous to mouse central Chr 8. Thus, on the basis of phenotype and map position, Cat4 may be a mouse model of human ASOD. The genes Junb, Jund1, Mel, and Zfp42 are discussed as possible candidates for Cat4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.