ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.
- Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors.Pharmacology, biochemistry, and behavior · 2019Pooled it
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- MC4R mutant mice develop ovarian teratomas.Scientific reports · 2021Article
- A most formidable arsenal: genetic technologies for building a better mouse.Genes & development · 2020Review
- Phenotypic characteristics of commonly used inbred mouse strains.Journal of molecular medicine (Berlin, Germany) · 2020Review
- The virtuous cycle of human genetics and mouse models in drug discovery.Nature reviews. Drug discovery · 2019Review
- Immune Surveillance by Natural IgM Is Required for Early Neoantigen Recognition and Initiation of Adaptive Immunity.American journal of respiratory cell and molecular biology · 2018Article
- The natural Disc1-deletion present in several inbred mouse strains does not affect sleep.Scientific reports · 2017Article
- Genomic landscapes of endogenous retroviruses unveil intricate genetics of conventional and genetically-engineered laboratory mouse strains.Experimental and molecular pathology · 2016Article
- Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection.Journal of virology · 2015Article
- Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles.PLoS genetics · 2015Article
- Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.Aging cell · 2014Article
- Comparison of inbred mouse substrains reveals segregation of maladaptive fear phenotypes.Frontiers in behavioral neuroscience · 2014Article
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- BRCA1 is a negative modulator of the PRC2 complex.The EMBO journal · 2013Article
- Genetically determined severity of anti-myeloperoxidase glomerulonephritis.The American journal of pathology · 2013Article
- Article
- Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis.Molecular metabolism · 2013Article
- Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The 129 mouse is the most widely used strain in gene targeting experiments. However, numerous substrains exist with demonstrable physiological differences. In this study a set of simple sequence length polymorphisms (SSLPs) was used to determine the relatedness of selected 129 substrains. 129/SvJ was significantly different from the other 129 substrains and is more accurately classified as a recombinant congenic strain (129cX/Sv), being derived from 129/Sv and an unknown strain. This mixed genetic background could complicate gene targeting experiments by reducing homologous recombination efficiency when constructs and ES cells are not derived from the same 129 substrain. Additionally, discrepancies due to different genetic backgrounds may arise when comparing phenotypes of genes targeted in different 129-derived ES cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.