ArticleThe Journal of cell biology1997
An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 177 citations in OpenAlex.
- An intermediate activation state primes Langerhans cell migration from the epidermis.bioRxiv : the preprint server for biology · 2025Article
- Fine Wrinkle Treatment and Hydration on the Facial Dermis Using HydroToxin Mixture of MicroBotox and MicroHyaluronic Acid.Aesthetic surgery journal · 2021Article
- Dendritic Cell-Targeted pH-Responsive Extracellular Vesicles for Anticancer Vaccination.Pharmaceutics · 2019Article
- Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.Blood · 2018Article
- Characterization of respiratory dendritic cells from equine lung tissues.BMC veterinary research · 2017Article
- Article
- Aggravation of Allergic Airway Inflammation by Cigarette Smoke in Mice Is CD44-Dependent.PloS one · 2016Article
- Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization.Scientific reports · 2015Article
- Article
- Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells.Molecular oncology · 2014Article
- Differential functional effects of biomaterials on dendritic cell maturation.Acta biomaterialia · 2012Article
- Hyaluronic acid: A key molecule in skin aging.Dermato-endocrinology · 2012Article
- Antigen-specific induction of osteopontin contributes to the chronification of allergic contact dermatitis.The American journal of pathology · 2010Article
- Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice.The Journal of clinical investigation · 2009Article
- Role of CD44 in the differentiation of Th1 and Th2 cells: CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion.Brain, behavior, and immunity · 2009Article
- Visualizing dendritic cell migration within the skin.Histochemistry and cell biology · 2008Review
- Regulated osteopontin expression by dendritic cells decisively affects their migratory capacity.The Journal of investigative dermatology · 2008Article
- Dendritic cells and contact dermatitis.Clinical reviews in allergy & immunology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon antigen contact, epidermal Langerhans cells (LC) and dendritic cells (DC) leave peripheral organs and home to lymph nodes via the afferent lymphatic vessels and then assemble in the paracortical T cell zone and present antigen to T lymphocytes. Since splice variants of CD44 promote metastasis of certain tumors to lymph nodes, we explored the expression of CD44 proteins on migrating LC and DC. We show that upon antigen contact, LC and DC upregulate pan CD44 epitopes and epitopes encoded by variant exons v4, v5, v6, and v9. Antibodies against CD44 epitopes inhibit the emigration of LC from the epidermis, prevent binding of activated LC and DC to the T cell zones of lymph nodes, and severely inhibit their capacity to induce a delayed type hypersensitivity reaction to a skin hapten in vivo. Our results demonstrate that CD44 splice variant expression is obligatory for the migration and function of LC and DC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.