ArticleThe Journal of cell biology1997
Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Engineering Stem Cells for Islet Replacement Therapy: Recent Advances and Barriers for Clinical Translation.Cells · 2026Review
- Stem Cell Therapy for the Management of Type 1 Diabetes: Advances and Perspectives.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Optimizing Generation of Stem Cell-Derived Islet Cells.Stem cell reviews and reports · 2022Review
- Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges.Stem cell research & therapy · 2022Review
- Recent developments in β-cell differentiation of pluripotent stem cells induced by small and large molecules.International journal of molecular sciences · 2014Review
- Article
- PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes.Journal of cell science · 2013Article
- PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Regulation of pancreas plasticity and malignant transformation by Akt signaling.Gastroenterology · 2009Article
- Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase.Biochemical and biophysical research communications · 2008Article
- p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells.Cell death and differentiation · 2008Article
- Stem cell therapy to treat diabetes mellitus.The review of diabetic studies : RDS · 2008Article
- Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinase.Molecular and cellular biochemistry · 2007Article
- Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors.Biochemical pharmacology · 2006Article
- Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells.British journal of pharmacology · 2004Article
- Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells.The Journal of experimental medicine · 2002Article
- Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation.Oncogene · 2000Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Phosphatidylinositol 3-kinase (PI3K) has been shown to be an important mediator of intracellular signal transduction in mammalian cells. We show here, for the first time, that the blockade of PI3K activity in human fetal undifferentiated cells induced morphological and functional endocrine differentiation. This was associated with an increase in mRNA levels of insulin, glucagon, and somatostatin, as well as an increase in the insulin protein content and secretion in response to secretagogues. Blockade of PI3K also increased the proportion of pluripotent precursor cells coexpressing multiple hormones and the total number of terminally differentiated cells originating from these precursor cells. We examined whether any of the recently described modulators of endocrine differentiation could participate in regulating PI3K activity in fetal islet cells. The activity of PI3K was inversely correlated with the hepatocyte growth factor/scatter factor-induced downregulation or nicotinamideinduced upregulation of islet-specific gene expression, giving support to the role of PI3K, as a negative regulator of endocrine differentiation. In conclusion, our results provide a mechanism for the regulation of hormone-specific gene expression during human fetal neogenesis. They also suggest a novel function for PI3K, as a negative regulator of cellular differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.