ArticleThe Journal of cell biology1997
A Chlamydomonas homologue of the putative murine t complex distorter Tctex-2 is an outer arm dynein light chain.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Light chain 2 is a Tctex-type related axonemal dynein light chain that regulates directional ciliary motility in Trypanosoma brucei.PLoS pathogens · 2022Article
- Consensus nomenclature for dyneins and associated assembly factors.The Journal of cell biology · 2022Article
- The sperm-associated antigen 6 interactome and its role in spermatogenesis.Reproduction (Cambridge, England) · 2019Article
- Ciliary Motility: Regulation of Axonemal Dynein Motors.Cold Spring Harbor perspectives in biology · 2017Review
- Subunit composition of the human cytoplasmic dynein-2 complex.Journal of cell science · 2014Article
- TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network.Biology open · 2013Article
- Association of Lis1 with outer arm dynein is modulated in response to alterations in flagellar motility.Molecular biology of the cell · 2012Article
- Partially functional outer-arm dynein in a novel Chlamydomonas mutant expressing a truncated gamma heavy chain.Eukaryotic cell · 2008Article
- Dyneins across eukaryotes: a comparative genomic analysis.Traffic (Copenhagen, Denmark) · 2007Article
- Genetic analysis of the cytoplasmic dynein subunit families.PLoS genetics · 2006Article
- Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.Journal of medical genetics · 2006Article
- Differential light chain assembly influences outer arm dynein motor function.Molecular biology of the cell · 2005Article
- The LC7 light chains of Chlamydomonas flagellar dyneins interact with components required for both motor assembly and regulation.Molecular biology of the cell · 2004Article
- Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body.The Journal of cell biology · 2004Article
- Article
- Backbone dynamics of the 8 kDa dynein light chain dimer reveals molecular basis of the protein's functional diversity.Journal of biomolecular NMR · 2002Article
- Insights into the structural organization of the I1 inner arm dynein from a domain analysis of the 1beta dynein heavy chain.Molecular biology of the cell · 2000Article
- LC2, the chlamydomonas homologue of the t complex-encoded protein Tctex2, is essential for outer dynein arm assembly.Molecular biology of the cell · 1999Article
- Domains in the 1alpha dynein heavy chain required for inner arm assembly and flagellar motility in Chlamydomonas.The Journal of cell biology · 1999Article
- The role of preassembled cytoplasmic complexes in assembly of flagellar dynein subunits.Molecular biology of the cell · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Molecular analysis of a 19,000-Mr protein from the Chlamydomonas flagellum reveals that it is homologous to the t complex-encoded protein Tctex-2, which is a candidate for one of the distorter products that cause the extreme transmission ratio distortion (meiotic drive) of the murine t complex. The 19,000-Mr protein is extracted from the axoneme with 0.6 M NaCl and comigrates with the outer dynein arm in sucrose density gradients. This protein also is specifically missing in axonemes prepared from a mutant that does not assemble the outer arm. These data raise the possibility that Tctex-2 is a sperm flagellar dynein component. Combined with the recent identification of Tctex-1 (another distorter candidate) as a light chain of cytoplasmic dynein, these results lead to a biochemical model for how differential defects in spermiogenesis that result in the phenomenon of meiotic drive might be generated in wild-type vs t-bearing sperm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.