ArticleThe Journal of cell biology1997
Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 103 citations in OpenAlex.
- Lineage-Specific Diversification of Nucleoporin Nup98 Genes in Ciliates and Its Evolutionary Implications for the Nuclear Dualism.Journal of molecular evolution · 2026Article
- Pathologies at the gateway: exploring the link between nucleoporins and inherited diseases.Cellular and molecular life sciences : CMLS · 2026Review
- TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport.Nature communications · 2024Article
- Overexpressed Nup88 stabilized through interaction with Nup62 promotes NF-κB dependent pathways in cancer.Frontiers in oncology · 2023Article
- Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes.Nature communications · 2020Article
- NUP214 deficiency causes severe encephalopathy and microcephaly in humans.Human genetics · 2019Article
- Moonlighting nuclear pore proteins: tissue-specific nucleoporin function in health and disease.Histochemistry and cell biology · 2018Review
- Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.PLoS genetics · 2018Article
- The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export.The Journal of biological chemistry · 2016Article
- Review
- Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1.The Journal of biological chemistry · 2013Article
- Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes.The EMBO journal · 2013Article
- LONO1 encoding a nucleoporin is required for embryogenesis and seed viability in Arabidopsis.Plant physiology · 2012Article
- Alterations in nuclear pore architecture allow cancer cell entry into or exit from drug-resistant dormancy.The American journal of pathology · 2012Article
- The nucleoporin Nup88 is interacting with nuclear lamin A.Molecular biology of the cell · 2011Article
- The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export.Molecular biology of the cell · 2010Article
- Nuclear pore proteins and cancer.Seminars in cell & developmental biology · 2009Review
- Herpes simplex virus replication: roles of viral proteins and nucleoporins in capsid-nucleus attachment.Journal of virology · 2009Article
- Nup53 is required for nuclear envelope and nuclear pore complex assembly.Molecular biology of the cell · 2008Article
- Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The short filaments extending from the cytoplasmic face of nuclear pore complexes are thought to contain docking sites for nuclear import substrates. One component of these filaments is the large O-linked glycoprotein CAN/Nup214. Immunoprecipitation studies carried out under nondenaturing conditions, and using a variety of antibodies, reveal a novel nonglycosylated nucleoporin, Nup84, that is tightly associated with CAN/Nup214. Consistent with such an association, Nup84 is found to be exposed on the cytoplasmic face of the nuclear pore complex. cDNA sequence analyses indicate that Nup84 contains neither the GLFG nor the XFXFG repeats that are a characteristic of a number of other nuclear pore complex proteins. Secondary structure predictions, however, suggest that Nup84 contains a coiled-coil COOH-terminal domain, a conclusion supported by the observation of significant sequence similarity between this region of the molecule and various members of the tropomyosin family. Mutagenesis and expression studies indicate that the putative coiled-coil domain is required for association with the cytoplasmic face of the nuclear pore complex, whereas it is the NH2-terminal region of Nup84 that contains the site of interaction with CAN/Nup214. These findings suggest a model in which Nup84 may function in the attachment of CAN/Nup214 to the central framework of the nuclear pore complex. In this way, Nup84 could play a central role in the organization of the interface between the pore complex and the cytoplasm.
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