ArticleArchives of disease in childhood1997
Inflammatory bowel disease and predisposition to osteopenia.
Article in Archives of disease in childhood, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Skeletal health of children and adolescents with inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2011Guideline
- Effect of titrated parenteral nutrition on body composition after allogeneic hematopoietic stem cell transplantation in children: a double-blind, randomized, multicenter trial.The American journal of clinical nutrition · 2012Trial
- Efficacy and harms of nasal calcitonin in improving bone density in young patients with inflammatory bowel disease: a randomized, placebo-controlled, double-blind trial.The American journal of gastroenterology · 2011Trial
- Effect of exclusive enteral nutrition on bone turnover in children with Crohn's disease.Journal of gastroenterology · 2010Trial
- A multi-center, randomized, controlled trial of parenteral nutrition titrated to resting energy expenditure in children undergoing hematopoietic stem cell transplantation ("PNTREE"): rationale and design.Contemporary clinical trials · 2010Trial
- Variable deficits of bone mineral despite chronic glucocorticoid therapy in pediatric patients with inflammatory diseases: a Glaser Pediatric Research Network study.Journal of pediatric endocrinology & metabolism : JPEM · 2006Trial
- Crohn's and bones: assessing bone microarchitecture using high-resolution peripheral quantitative computed tomography.JBMR plus · 2026Article
- DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone.Scientific reports · 2019Article
- Vitamin D Status and Bone Mineral Density in Children with Inflammatory Bowel Disease Compared to Those with Functional Abdominal Pain.Journal of Korean medical science · 2017Article
- Glucocorticoid-associated osteoporosis in chronic inflammatory diseases: epidemiology, mechanisms, diagnosis, and treatment.Current osteoporosis reports · 2014Review
- Use of exclusive enteral nutrition is just as effective as corticosteroids in newly diagnosed pediatric Crohn's disease.Digestive diseases and sciences · 2013Article
- The early onset of disease may be a risk factor for decreased bone mineral density in patients with inflammatory bowel disease.Clinical endoscopy · 2013Article
- Fibroblast growth factor 23 contributes to diminished bone mineral density in childhood inflammatory bowel disease.BMC gastroenterology · 2012Article
- An exploratory analysis of healthcare costs and utilization of pediatric patients with Crohn's disease.Digestive diseases and sciences · 2009Article
- Growth hormone treatment for growth failure in pediatric patients with Crohn's disease.The Journal of pediatrics · 2008Article
- Risk factors for low bone mineral density in children and adolescents with inflammatory bowel disease.Digestive diseases and sciences · 2008Article
- Chronic pediatric inflammatory diseases: effects on bone.Reviews in endocrine & metabolic disorders · 2008Review
- Article
- Exercise and Crohn's disease: speculations on potential benefits.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2006Review
- The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease.Pediatric radiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of osteopenia in children with inflammatory bowel disease (IBD) is unknown. The effect of nutritional state, disease activity, and steroid therapy on bone mineral content (BMC) of whole body, lumbar spine, and left femoral neck measured by dual energy x ray absorptiometry in 32 children with IBD was assessed by comparison with 58 healthy local school children. Using the control data, a predicted BMC was calculated taking into account bone area, age, height, weight, and pubertal stage. The measured BMC in children with IBD was expressed as a percentage of this predicted value (% BMC). Mean (SD) % BMC was significantly reduced for the whole body and left femoral neck in the children with IBD (97.0 (4.5)% and 93.1 (12.0)% respectively, p < 0.05). Of the children with IBD, 41% had a % BMC less than 1 SD below the mean for the whole body and 47% at the femoral neck. Reduction in % BMC was associated with steroid usage but not with the magnitude of steroid dose, disease activity, or biochemical markers of bone metabolism. In conclusion, osteopenia is relatively common in childhood IBD and may be partly related to the previous use of steroids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.