ArticleThe Plant cell1997
Reduced naphthylphthalamic acid binding in the tir3 mutant of Arabidopsis is associated with a reduction in polar auxin transport and diverse morphological defects.
Article in The Plant cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 312 citations in OpenAlex.
- Single and multiple buds form characteristics in Amorphophallus muelleri.Plant reproduction · 2026Article
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- Ubiquitin E3 ligases in the plant Arg/N-degron pathway.The Biochemical journal · 2024Review
- BIG enhances Arg/N-degron pathway-mediated protein degradation to regulate Arabidopsis hypoxia responses and suberin deposition.The Plant cell · 2024Article
- Protein degradation in auxin response.The Plant cell · 2024Review
- BIG coordinates auxin and SHORT ROOT to promote asymmetric stem cell divisions in Arabidopsis roots.Plant cell reports · 2024Article
- An auxin research odyssey: 1989-2023.The Plant cell · 2024Review
- The Efficiency of CBD Production Using GraftedPlants (Basel, Switzerland) · 2024Article
- Auxin regulates bulbil initiation by mediating sucrose metabolism inHorticulture research · 2024Article
- Auxin Involvement in Ceratopteris Gametophyte Meristem Regeneration.International journal of molecular sciences · 2023Article
- Different evolutionary patterns of TIR1/AFBs and AUX/IAAs and their implications for the morphogenesis of land plants.BMC plant biology · 2023Article
- Precise Regulation of the TAA1/TAR-YUCCA Auxin Biosynthesis Pathway in Plants.International journal of molecular sciences · 2023Review
- Genome-wide identification and expression profiling of B3 transcription factor genes inFrontiers in plant science · 2023Article
- The calcium signaling module CaM-IQM destabilizes IAA-ARF interaction to regulate callus and lateral root formation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- BIG Modulates Stem Cell Niche and Meristem Development via SCR/SHR Pathway in Arabidopsis Roots.International journal of molecular sciences · 2022Article
- Illuminating the molecular mechanisms underlying shoot apical meristem homeostasis in plants.Plant biotechnology (Tokyo, Japan) · 2022Article
- Structural Aspects of Auxin Signaling.Cold Spring Harbor perspectives in biology · 2022Review
- Elevated COPlants (Basel, Switzerland) · 2021Review
- Naphthylphthalamic acid associates with and inhibits PIN auxin transporters.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Involvement of Arabidopsis BIG protein in cell death mediated by Myo-inositol homeostasis.Scientific reports · 2020Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Polar auxin transport plays a key role in the regulation of plant growth and development. To identify genes involved in this process, we have developed a genetic procedure to screen for mutants of Arabidopsis that are altered in their response to auxin transport inhibitors. We recovered a total of 16 independent mutants that defined seven genes, called TRANSPORT INHIBITOR RESPONSE (TIR) genes. Recessive mutations in one of these genes, TIR3, result in altered responses to transport inhibitors, a reduction in polar auxin transport, and a variety of morphological defects that can be ascribed to changes in indole-3-acetic acid distribution. Most dramatically, tir3 seedlings are strongly deficient in lateral root production, a process that is known to depend on polar auxin transport from the shoot into the root. In addition, tir3 plants display a reduction in apical dominance as well as decreased elongation of siliques, pedicels, roots, and the inflorescence. Biochemical studies indicate that tir3 plants have a reduced number of N-1-naphthylphthalamic (NPA) binding sites, suggesting that the TIR3 gene is required for expression, localization, or stabilization of the NPA binding protein (NBP). Alternatively, the TIR3 gene may encode the NBP. Because the tir3 mutants have a substantial defect in NPA binding, their phenotype provides genetic evidence for a role for the NBP in plant growth and development.
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