ArticleJournal of clinical microbiology1997
Comparative analysis of genetic variability among Candida albicans isolates from different geographic locales by three genotypic methods.
Article in Journal of clinical microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Random amplification of polymorphic DNA and microsatellite genotyping of pre- and posttreatment isolates of Candida spp. from human immunodeficiency virus-infected patients on different fluconazole regimens.Journal of clinical microbiology · 1998Trial
- Genetic Diversity ofPathogens (Basel, Switzerland) · 2022Article
- Typing Candida albicans oral isolates from healthy brazilian schoolchildren using multilocus enzyme electrophoresis reveals two highly polymorphic taxa.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- Candida albicans: genotyping methods and clade related phenotypic characteristics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- Genetic relatedness of commensal strains of Candida albicans carried in the oral cavity of patients' dental prosthesis users in Brazil.Mycopathologia · 2007Article
- Clonal population structure and genetic diversity of Candida albicans in AIDS patients from Abidjan (Côte d'Ivoire).Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Molecular analysis and susceptibility profiling of Candida albicans isolates from immunocompromised patients in South India.Mycopathologia · 2006Article
- Population structure and properties of Candida albicans, as determined by multilocus sequence typing.Journal of clinical microbiology · 2005Article
- Genetic diversity among clinical isolates of Candida glabrata analyzed by randomly amplified polymorphic DNA and multilocus enzyme electrophoresis analyses.Journal of clinical microbiology · 2003Article
- Primers ITS1, ITS2 and ITS4 detect the intraspecies variability in the internal transcribed spacers and 5.8S rRNA gene region in clinical isolates of fungi.Folia microbiologica · 2003Article
- Genetic diversity and biochemical characteristics of Trichosporon asahii isolated from clinical specimens, houses of patients with summer-type-hypersensitivity pneumonitis, and environmental materials.Journal of clinical microbiology · 2001Article
- Typing of Candida albicans isolates by sequence analysis of the cytochrome b gene and differentiation from Candida stellatoidea.Journal of clinical microbiology · 2001Article
- Candidiasis during pregnancy may result from isogenic commensal strains.Infectious diseases in obstetrics and gynecology · 2001Article
- Comparative genotyping of Candida albicans bloodstream and nonbloodstream isolates at a polymorphic microsatellite locus.Journal of clinical microbiology · 2000Article
- The ins and outs of DNA fingerprinting the infectious fungi.Clinical microbiology reviews · 2000Review
- Pentamidine inhibition of group I intron splicing in Candida albicans correlates with growth inhibition.Antimicrobial agents and chemotherapy · 2000Article
- Clonal and spontaneous origins of fluconazole resistance in Candida albicans.Journal of clinical microbiology · 2000Article
- Species and genotypic diversities and similarities of pathogenic yeasts colonizing women.Journal of clinical microbiology · 1999Article
- Phylogenetic relationships of varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum Darling.Journal of clinical microbiology · 1999Article
- Molecular and phenotypic characterization of genotypic Candida albicans subgroups and comparison with Candida dubliniensis and Candida stellatoidea.Journal of clinical microbiology · 1999Article
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4 authors.
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Abstract
The objective of the present study was to conduct a comparative genotypic analysis of Candida albicans isolates from the United States, Europe, and Southeast Asia to determine whether differences between isolates might be associated with geographic locations. The genotypes of 86 unrelated isolates of C. albicans (from the United States and Europe) and 26 isolates from Singapore were examined by three DNA typing methods. Computer-assisted methods were used to analyze the gel patterns for all isolates. A dendrogram based on the overall similarity of the patterns obtained by restriction endonuclease analysis (REA) with EcoRI clustered the U.S. and European isolates into two major groups (groups A and B). The Singaporean isolates demonstrated unique REA profiles, with nine isolates having both or neither of the REA-characteristic 3.7- and 4.2-kb bands present in groups A and B. By REA profiles, the Singaporean isolates were related to each other with similarity values (S(AB)s) of > 0.80, but only one isolate mixed with the U.S. and European isolates at this S(AB) (an arbitrary threshold for genetic similarity). Randomly amplified polymorphic DNA (RAPD) analysis generated DNA profiles that clustered the C. albicans isolates into approximately the same number of distinct typing groups as REA. However, isolates identical to each other by REA were generally different from each other by RAPD analysis. In a composite dendrogram prepared from the results obtained by RAPD analysis, the isolates from the United States and Europe clustered in major groups with S(AB)s of > 0.85, while Singaporean isolates connected to these clusters at S(AB)s of > or = 0.75. Pulsed-field gel electrophoresis was less discriminatory, discerning about one-third as many distinct subtypes as REA or RAPD analysis; the Singaporean isolates were distributed randomly with the U.S. and European isolates. These results suggest that a high degree of genetic diversity exists between C. albicans isolates from Southeast Asia and those from the United States and Europe.
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